Abstract
The effect of chemotherapy on subjects with primary amyloidosis (AL-amyloidosis) were studied with MRI in five patients. The MRI was performed every 3–5 months for 23–60 months, and the T1 and T2 relaxation times were determined in liver and subcutaneous fat. In the patients as a whole T1 was significantly prolonged (P < 0.05), whereas T2 was within normal range. On follow-up with repeated MRI increasing T1 values could be measured in progressive disease (one patient) whereas decreasing T1 values seemed to parallel clinical improvements in four patients. The effect of different treatment schedules in AL-amyloidosis may be evaluated with MRI and the amount of amyloid deposits may be quantified.
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References
Glenner GG (1980) Amyloid deposits and amyloidosis. The beta-fibrilloses. N Engl J Med 302: 1283–1292; 1333–1343
Baltz ML, Caspi D, Evans DJ et al. (1986) Circulating serum amyloid P component in the precursor of amyloid P component in tissue amyloid deposits. Clin Exp Immunol 66: 691–700
Pear LB (1986) Other organs and other amyloids. Semin Roentgenol 21: 154–155
Kyle RA, Greipp PR (1983) Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc 58: 665–683
Glenner GG, Terry W, Harada M et al. (1971) Amyloid fibril proteins. Proof of homology with immunoglobulin light chains by sequence analysis. Science 172: 1150–1151
Hawkins PN, Lavender JP, Pepys MB (1990) Evaluation of systemic amyloidosis by scintigraphy with 123I-labeled serum amyloid P component. N Engl J Med 323: 508–513
Kyle RA, Greipp MA, Garton JP et al. (1985) Primary systemic amyloidosis. Comparison of Melphalan/Prednisone versus Colchicine. Am J Med 79: 708–710
Benson L, Hemmingsson A, Ericsson A et al. (1987) Magnetic resonance in primary amyloidosis. Acta Radiol 28: 13–15
Westermark P, Stenkvist B (1973) A new method for the diagnosis of systemic amyloidosis. Arch Intern Med 132: 522–524
Westermark P, Benson L, Olofsson BO (1986) Fine needle aspiration biopsy of abdominal subcutaneous fat tissue for the diagnosis and typing of amyloidosis. In: Glenner GG, Osseman EF, Benditt EP et al. (eds) Amyloidosis. Plenum Press, New York, pp 613–615
Benson L, Westermark P, Cullhed I (1985) Chemotherapy in primary amyloidosis (abstract) Third European Conference on Oncology, Stockholm, p 35
Thuomas K-Å (1987) Aspects of image intensity and relaxation time assessment in magnetic resonance imaging. An experimental and clinical study. Acta Radiol (Suppl) 375: 49–90
Nyman R, Ericsson A, Hemmingsson A et al. (1986) T1, T2, and relative proton density at 0.35 T for spleen, liver, adipose tissue, and vertebral body: normal values. Magn Reson Med 3: 901–910
Farrar TC, Becker ED (1971) Pulse and Fourier transform NMR: introduction to theory and methods. Academic Press, New York, pp 1–85
Crawely AP, Henkelman RM (1987) Errors in T2 estimations using multislice echo imaging. Magn Res Med 4: 34–47
Just M, Higer HP, Pfannenstiel P (1988) Errors in T1 determination using multislice technique and Gaussian slice profile. Magn Reson Imaging 6: 53–56
Rafal RB, Jennis R, Kosovsky PA et al. (1990) MRI of primary amyloidosis. Gastrointest Radiol 15: 199–202
Sueoka BL, Kasales CJ, Harris RD et al. (1989) MR and CT imaging of perirenal amyloidosis. Urol Radiol 11: 97–99
Gean-Marton AD, Kirsch CFE, Veniza LG et al. (1991) Focal amyloidosis of the head and neck: evaluation with CT and MR imaging. Radiology 181: 521–525
Metzler JP, Fleckenstein JL, White III CL et al. (1992) MRI evaluation of amyloid myopathy. Skeletal Radiol 21: 463–465
Kokubo T, Takatori Y, Okutso I et al. (1990) MR demonstration of intraosseous beta-2-microglobulin amyloidosis. J Comput Assist Tomogr 14: 1030–1032
Olliff JFC, Hardy JR, Williams MP et al. (1989) Case report: magnetic resonance imaging of spinal amyloid. Clin Radiol 40: 632–633
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Correspondence to: K.-Å. Thuomas
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Thuomas, KÅ., Benson, L., Westermark, P. et al. Long-term follow-up of patients with primary amyloidosis with MRI. Eur. Radiol. 4, 452–457 (1994). https://doi.org/10.1007/BF00212820
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DOI: https://doi.org/10.1007/BF00212820