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Looking into the future: iotrolan and beyond

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Abstract

The modern classes of contrast agents in the diagnostic areas of X-ray, magnetic resonance and ultrasound imaging offer safety and tolerance on a level which is difficult to further improve. The thrust of research is, therefore, now focused on efficacy, which basically means the development of organ and tissue-specific contrast agents. These new substance classes promise to open up faseinating possibilities and are represented in this review by specific agents that are currently undergoing preclinical or clinica evaluation. Reficulo-endothelial systems and hepatocyte-targeted agents enhance the tissue contrast of the liver and spleen, reducing the detection threshold and facilitating further characterization of focal liver lesions. With blood pool contrast agetns it is possible to delincate blood vessesl and obtain an angiographic effect for detection of areas of increased capillary permeability and occult bleeding.

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Authors and Affiliations

  1. Clinical Research and Development Diagnostics, D-13353, Schering AG, Mütillerstrasse 178, Berlin, Germany

    H. P. Niendorf, T. Fritzsch, G. Herrschaft, W. Krause, A. Muffler & R. Schürmann

Authors
  1. H. P. Niendorf
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  2. T. Fritzsch
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  3. G. Herrschaft
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  4. W. Krause
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  5. A. Muffler
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  6. R. Schürmann
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Niendorf, H.P., Fritzsch, T., Herrschaft, G. et al. Looking into the future: iotrolan and beyond. Eur. Radiol. 5 (Suppl 2), S107–S111 (1995). https://doi.org/10.1007/BF02343274

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  • DOI: https://doi.org/10.1007/BF02343274

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