Abstract
Acoustic schwannoma is a slow-growing tumor and usually occurs in adult patients. We report a rare pediatric case of acoustic schwannoma with high proliferative potential. A 10-year-old boy was diagnosed as having a right cerebellopontine angle tumor. The tumor was subtotally resected. Histological examination revealed a typical acoustic schwannoma with a few mitotic figures. Chromosomal analysis showed no abnormality on the long arm of chromosome 22 associated with neurofibromatosis type 2. The lesion regrew rapidly as an acoustic schwannoma, necessitating subtotal resection on three occasions and CyberKnife radiosurgery. The immunohistochemical MIB-1 staining indices of the specimens obtained at the first, second, and third operations were 2.3%, 4.6% and 14.7%, respectively. The immunohistochemical proliferative potential of acoustic schwannoma is discussed.
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Received: 6 February 1999 Revised: 8 April 1999
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Harada, K., Nishizaki, T., Adachi, N. et al. Pediatric acoustic schwannoma showing rapid regrowth with high proliferative activity. Child's Nerv Syst 16, 134–137 (2000). https://doi.org/10.1007/s003810050479
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DOI: https://doi.org/10.1007/s003810050479