Abstract
Records of 92 children were reviewed who, in the first 18 months of life had an intracranial tumour, and who were registered with the Manchester Children's Tumour Registry during the 34-year period from 1953 to 1987. The incidence of intracranial tumour was 1 in 25000 live births, and 85% of the tumours were malignant. The introduction of computed tomography (CT) in the region in 1976 improved the diagnostic accuracy and led to early diagnosis. This also coincided with refined radiotherapy and improved chemotherapy. The surgical attitude became more aggressive, and with early treatment, mortality was reduced, though the 1-month operative mortality still remains high at 15%. All survivors were available for follow-up. All children with axial tumours died within 9 years. Long-term follow-up did not suggest significant improvement in the overall survival or in the quality of life, though there was a significant improvement in the 5-year survival rate with modern management.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Armitage P (1971) Statistical methods in medical research. Blackwell, Oxford, pp 408–415
Asai A, Hoffmann HJ, Hendrick EB, Humphreys RP, Becker LE (1989) Primary intracranial neoplasms in the first year of life. Child's Nerv Syst 5:230–233
Birch JM, Marsden HB, Morris Jones PM, Pearson D, Blair V (1988) Significant improvements in survival in childhood cancer: results of a population-based survey spanning thirty years. Br Med J 296:1372–1376
Farwell JR, Dohrmann GJ, Flannery JT (1978) Intracranial neoplasms in infants. Arch Neurol 35:533–537
Fessard C (1968) Cerebral tumors in infancy. Am J Dis Child 115:302–308
Jennett B, Bond M (1975) Assessment of outcome after severe brain damage: a practical scale. Lancet I:480–484
Jooma R, Hayward RD, Grant DN (1984) Intracranial neoplasms during the first year of life: analysis of one hundred consecutive cases. Neurosurgery 14:31–41
Koos WT, Miller MH (1971) Intracranial tumors of infants and children. Thieme, Stuttgart, pp 9–27
Kretzschmar K (1982) Follow-up studies of brain tumors infants. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 130–141
Lapras C, Guilburd JN, Guyotat J, Patet JD (1988) Brain tumors in infants: a study of 76 patients operated upon. Child's Nerv Syst 4:100–103
Matson DD (1964) Intracranial tumours of first two years of life. West J Surg Obstet Gynecol 72:117–122
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis or randomised clinical trials requiring prolonged observations on each patient. II. Analysis and examples. Br J Cancer 35:1–39
Ramondi AJ, Tomita T (1983) Brain tumors during the first year of life. Child's Brain 10:193–207
Sato A, Tamura A, Sano K (1975) Brain tumors of early infants. Child's Brain 1:121–125
Tomita T, McLone DG (1985) Brain tumors during the first twenty-four months of life. Neurosurgery 17:913–919
World Health Organisation (1976) ICD-O International Classification of Diseases for Oncology. World Health Organisation, Geneva
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kumar, R., Jones, R.A.C. & Tekkök, I.H. Has modern management improved the outcome of infants with intracranial tumours?. Child's Nerv Syst 6, 327–330 (1990). https://doi.org/10.1007/BF00298278
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00298278