Abstract
A 32-day-old boy died of recurring cerebral hemorrhages starting on the 4th day of life. Autopsy disclosed a remittingly ruptured saccular aneurysm of the anterior communicating artery. A 7-day-old brother of his had previously died of recurring subarachnoid hemorrhages as well. The young age of the patient, the site of the aneurysm, and its probably familial occurrence make this case a unique one. Nonaneurysmatic basal cerebral arteries showed remarkable histological changes partly resembling those seen in fibromuscular dysplasia, some of them probably representing preaneurysmatic alterations. A known underlying systemic disease could not be found, and immunohistochemical detection of type III collagen revealed no identifiable deficiency.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Almeida GM, Pindaro J, Plese P, Bianco E, Shibata MK (1977) Intracranial arterial aneurysms in infancy and childhood. Child's Brain 3:193–199
Amacher AL, Drake CG (1979) The results of operating upon cerebral aneurysms and angiomas in children and adolescents. I. Cerebral aneurysms. Child's Brain 5:151–165
Bannerman RM, Ingall GB, Graf CJ (1970) The familial occurrence of intracranial aneurysms. Neurology 20:283–292
Bolander H, Hassler O, Liliequist B, West KA (1978) Cerebral aneurysm in an infant with fibromuscular hyperplasia of the renal arteries. Case report. J Neurosurg 49:756–759
Cedzich C, Schramm J, Röckelein G (1990) Multiple middle cerebral artery aneurysms in an infant. Case report. J Neurosurg 72:806–809
De Paepe A, Landegem W van, Keyser F de, Reuck J de (1988) Association of multiple intracranial aneurysms and collagen type III deficiency. Clin Neurol Neurosurg 90:53–56
Ferrante L, Fortuna A, Celli P, Santoro A, Fraioli B (1988) Intracranial arterial aneurysms in early childhood. Surg Neurol 29:39–56
Ferry PC, Kerber C, Peterson D, Gallo AA Jr (1974) Arteriectasis, subarachnoid hemorrhage in a three-month-old infant. Neurology 24:494–500
Fox JL, Ko JP (1980) Familial intracranial aneurysms. Six cases among 13 siblings. J Neurosurg 52:501–503
Gerosa M, Licata C, Fiore DL, Iraci G (1980) Intracranial aneurysms of childhood. Child's Brain 6:295–302
Halal F, Mohr G, Toussi T, Martinez SN (1983) Intracranial aneurysms: a report of a large pedigree. Am J Med Genet 15:89–95
Hashimoto I (1977) Familial intracranial aneurysms and cerebral vascular anomalies. J Neurosurg 46:419–427
Hungerford GD, Marzluff JM, Kempe LG, Powers JM (1981) Cerebral arterial aneurysm in a neonate. Neuroradiology 21:107–110
Leblanc R, Lozano AM, Rest M van der, Guttmann RD (1989) Absence of collagen deficiency in familial cerebral aneurysms. J Neurosurg 70:837–840
Lipper S, Morgan D, Krigman MR, Staab EV (1978) Congenital saccular aneurysm in a 19-day-old neonate: case report and review of the literature. Surg Neurol 10:161–165
Lozano AM, Leblanc R (1987) Familial intracranial aneurysms. J Neurosurg 66:522–528
Meyer FB, Sundt TM Jr, Fode NC, Morgan MK, Forbes GS, Mellinger JF (1989) Cerebral aneurysms in childhood and adolescence. J Neurosurg 70:420–425
Neil-Dwyer G, Bartlett JR, Nicholls AC, Narcisi P, Pope FM (1983) Collagen deficiency and ruptured cerebral aneurysms. A clinical and biochemical study. J Neurosurg 59:16–20
Nishio A, Sakaguchi M, Murata K, Egashira M, Yamada T, Izuo M, Nakanishi N (1991) Anterior communicating artery aneurysm in early childhood. Report of a case. Surg Neurol 35:224–229
Norrgård Ö, Ängquist KA, Fodstad H, Forsell Å, Lindberg M (1987) Intracranial aneurysms and heredity. Neurosurgery 20:236–239
Østergaard JR, Oxlund H (1987) Collagen type III deficiency in patients with rupture of intracranial saccular aneurysms. J Neurosurg 67:690–696
Patrick D, Appleby A (1983) Familial intracranial aneurysm and infundibular widening. Neuroradiology 25:329–334
Pope FM, Martin GR, Lichtenstein JR, Penttinen R, Gerson B, Rowe DW, McKusick VA (1975) Patients with Ehlers-Danlos syndrome type IV lack type III collagen. Proc Natl Acad Sci USA 72:1314–1316
Sandok BA (1989) Fibromuscular dysplasia of the cephalic arterial system. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 55: Vascular diseases, part III. Elsevier, Amsterdam, pp 283–292
Schievink WI, Limburg M, Oorthuys JWE, Fleury P, Pope FM (1990) Cerebrovascular disease in Ehlers-Danlos syndrome type IV. Stroke 21:626–632
Sekhar LN, Heros RC (1981) Origin, growth, and rupture of saccular aneurysms: a review. Neurosurgery 8:248–260
Shinton R, Palsingh J, Williams B (1991) Cerebral haemorrhage and berry aneurysm: evidence from a family for a pattern of autosomal dominant inheritance. J Neurol Neurosurg Psychiatr 54:838–840
Stehbens WE (1963) Histopathology of cerebral aneurysms. Arch Neurol 8:272–285
Stehbens WE (1989) Etiology of intracranial berry aneurysms. J Neurosurg 70:823–831
Ter Berg HWM, Bijlsma JB, Willemse J (1987) Familial occurrence of intracranial aneurysms in childhood: a case report and review of the literature. Neuropediatrics 18:227–230
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kuchelmeister, K., Schulz, R., Bergmann, M. et al. A probably familial saccular aneurysm of the anterior communicating artery in a neonate. Child's Nerv Syst 9, 302–305 (1993). https://doi.org/10.1007/BF00306281
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00306281