Skip to main content
SpringerLink
Log in

Urinary enzyme excretion patterns in children

  • Original Articles
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

The need for a sensitive marker of renal parenchymal damage in children remains extant. The detection of renal scarring is presently dependant upon imaging modalities with the implicit problems of exposure to radiological investigation. We describe and evaluate urinary enzymology as a technique that may identify injury to the renal parenchyma from a variety of patho-physiological conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Taylor DG, Price RG, Robinson D (1971) The distribution of some hydrolases in glomeruli and tubular fragments prepared from rat kidney by zonal centrifugation. Biochem J 122: 641–645

    Google Scholar 

  2. Guder WG, Ross BD (1984) Enzyme distribution along the nephron. Kidney Int 26: 101–111

    Google Scholar 

  3. Soejima A, Nagasawa MD (1983) Fundamental study on assay method of urinary N-acetyl-B-D-glucosaminidase and change of the activity in primary glomerulonephritis. Jap J Clin Path [Suppl] 56: 122

    Google Scholar 

  4. Wellwood JM, Ellis BG, Price RG, Hammond K, Thomson AE, Jones NF (1975) Urinary N-acetyl-B-D-glucosaminidase in patients with renal disease. BMJ 3: 408–411

    Google Scholar 

  5. Proctor AR, Kunin CM (1978) Salicylate induced enzymuria. Am J Med 65: 987–993

    Google Scholar 

  6. Whiting PH, Ross IS, Borthwick L (1979) Serum and urine N-acetyl-B-D-glucosaminidase in diabetics on diagnosis and subsequent treatment, and stable insulin dependent diabetics. Clin Chim Acta 92: 459–463

    Google Scholar 

  7. Johnston IDA, Jones NF, Scoble JE, Yeun CT, Price RG (1983) The diagnostic value of urinary enzyme measurements in hypertension. Clin Chim Acta 133: 317–325

    Google Scholar 

  8. Coward RA, De Lamore IW, Mallick NP, Robinson LE (1984) Urinary N-acetyl-B-D-glucosaminidase as an indicator of tubular damage in multiple myeloma. Clin Chim Acta 138: 293–298

    Google Scholar 

  9. Whiting PH, King DJ, Ireland A, Ratcliffe MA, Dawson AA (1986) N-acetyl-B-D-glucosaminidase enzymuria in leukaemia and myelomatosis: effect of treatment in acute myeloblastic leukaemia and myelomatosis in adults. Ann Clin Biochem 23: 676–680

    Google Scholar 

  10. Anderson DN, Rothnie IJ, Broom J, Keenan RA, Whiting PH (1992) Glomerulo-tubular function in patients undergoing moderate surgical stress. Ren fail 14: (2): 169–173

    Google Scholar 

  11. Whiting PH, Nicholls AJ, Catto GRD, Edward N, Engeset J (1980) Patterns of N-acetyl-B-D-glucosaminidase excretion after renal transplantation. Clin Chim Acta 108: 1–7

    Google Scholar 

  12. Diener U, Knoll E, Langer B, Rautenstrauch H, Ratge D, Wisser H (1981) Urinary excretion of N-acetyl-B-D-glucosaminidase and alanine aminopeptidase in patients receiving amikin or cis-platinum. Clin Chim Acta 112: 149–157

    Google Scholar 

  13. Redondo FL, Bergon E, Tinture T, Miravalles EM, Paseval T (1987) Urinary enzyme activities in patients treated with gold and other anti-rheumatic drugs. Clin Biochem 20: 343–347

    Google Scholar 

  14. Alberti Z, Orlowski M, Szewczuk A (1961) Histochemical demonstration of gamma-glutamyl transpeptidase. Nature 191: 767–768

    Google Scholar 

  15. Horpacsy G, Zinsmeyer J, Schroder K, Mebel M (1977) Value of determining urinary enzymes after human kidney transplantation: early warning of rejection or not. Clin Chem 23: 770–771

    Google Scholar 

  16. Ward JP (1976) Urinary gamma-glutamyl transpeptidase, an indicator of renal ischaemic injury and homograft rejection. Br J Urology 47: 765–770

    Google Scholar 

  17. Price RG (1982) Urinary enzymes, nephrotoxicity and renal disease. Toxicology 23: 99–134

    Google Scholar 

  18. Osborne J (1980) Urinary excretion of N-acetyl-B-D-glucosaminidase in children. Arch Dis Child 55: 719–721

    Google Scholar 

  19. Feldman D, Flandrois C, Jardel A, Phan T-M, Ayward P (1989) Circadian variations and reference intervals for some enzymes in the urine of healthy children. Clin Chem 35: 864–867

    Google Scholar 

  20. Langhendries JP, Gillain N, Battisti O, Carlier B, Bertrand JM (1987) Normal values for urinary N-acetyl-B-D-glucosaminidase excretion in preterm and term babies. Arch Dis Child 62: 483–486

    Google Scholar 

  21. Houser MT (1986) The effects of age and urine concentration on lysozyme and N-acetyl-B-D-glucosaminidase content in urine. Ann Clin Biochem 23: 297–302

    Google Scholar 

  22. Kunin CM, Chesney RW, Craig WA, England AG, De Angelis C (1978) Enzymuria as a marker of renal injury and disease: studies of N-acetyl-B-D-glucosaminidase in the general population and in patients with renal disease. Pediatrics 62: 751–760

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Paediatric Surgery, Royal Aberdeen Children's Hospital, Cornhill Road, AB9 2ZG, Aberdeen, UK

    D. N. Anderson, C. P. Driver & G. G. Youngson

  2. Department of Chemical Pathology, University of Aberdeen Medical School, AB9 2ZD, Foresterhill, Aberdeen, UK

    P. H. Whiting

Authors
  1. D. N. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. H. Whiting
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. P. Driver
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. G. Youngson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anderson, D.N., Whiting, P.H., Driver, C.P. et al. Urinary enzyme excretion patterns in children. Pediatr Surg Int 10, 111–114 (1995). https://doi.org/10.1007/BF00171168

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00171168

Key words

Search

Navigation