Abstract
Autologous splenic fragments regenerate after transplantation. The regenerated mass only attains a small proportion of that of the normal spleen. Some data on the protective function are controversial. Malaria parasites were inoculated to test splenic function in rats. Peak parasitemia, the course of parasitemia, and anemia were comparable in normal and autotransplanted rats. In rats with splenic transplants only the duration of the parasitemia was longer than in normal rats. In contrast, splenectomized rats were unable to clear the parasites from the blood and became progressively anemic. After stimulating regeneration by increasing the work load to the white pulp or the macrophage system, more regenerated tissue was found, but the protective function did not increase. The amount of regenerated splenic tissue does not correlate with its protective function.
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Pabst, R., Westermann, J., Hillebrand, J. et al. Protective effect of stimulated splenic transplants against rodent malaria — preliminary results. Pediatr Surg Int 3, 338–342 (1988). https://doi.org/10.1007/BF00189172
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DOI: https://doi.org/10.1007/BF00189172