Skip to main content
SpringerLink
Log in

Effect ofl-DOPA on motor behavior in a rat with a unilateral striatal neoplasm

  • Short Original Communications
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

After administration ofl-DOPA to a rat with a unilateral striatal neoplasm of the nucleus caudatus-putamen, postural asymmetries and rotating behavior were observed. These observations are discussed in relation to the activity of catecholamines within the central nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Andén, N.-E.: Pharmacological and anatomical implications of induced abnormal movements, pp. 132–142. In: L-DOPA and Parkinsonism. Eds. A. Barbeau and F. H. McDowell. Philadelphia: F. A. Davis Co. 1970.

    Google Scholar 

  • — Dahlstrom, A., Fuxe, K., Larsson, K.: Functional role of the nigro-neostriatal dopamine neurons. Acta pharmacol. (Kbh.)24, 263–274 (1966).

    Google Scholar 

  • Fuxe, K., Ungerstedt, U.: Histochemical, biochemical, and functional studies on central monoamine neurons after acute and chronic amphetamine administration, pp. 257–288. In: Amphetamines and related compounds Eds. E. Costa and S. Garattini. New York: Raven Press 1970.

    Google Scholar 

  • König, J. F. R., Klippel, R. A.: The rat brain. Baltimore: Williams and Wilkens Co. 1963.

    Google Scholar 

  • Lotti, V. J.: Action of various centrally acting agents in mice with unilateral caudate brain lesions. Life Sci.10 781–789 (1971).

    Google Scholar 

  • Ungerstedt, W., Arbuthnott, G. W.: Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res.24, 485–493 (1970).

    Google Scholar 

  • —, Butcher, L. L., Butcher, S. G., Andén, N.-E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum in the rat. Brain Res.14, 461–471 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, Northwestern University Medical School, 303 East Chicago Avenue, 60611, Chicago, Illinois, USA

    D. Griffith, R. Narotzky & D. McLone

Authors
  1. D. Griffith
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Narotzky
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. McLone
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by United States Public Health Service Research Grants NB 07044 and 1 S01 FR 5370 10.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Griffith, D., Narotzky, R. & McLone, D. Effect ofl-DOPA on motor behavior in a rat with a unilateral striatal neoplasm. Acta Neuropathol 22, 269–271 (1972). https://doi.org/10.1007/BF00684530

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00684530

Key words

Search

Navigation