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Neurofibrillary tangles in patients with Down's syndrome: A light and electron microscopic study

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Summary

Two older patients with Down's syndrome and widespread neurofibrillary tangles and senile plaques were studied by light and electron microscopy. The ultrastructural demonstration of twisted tubules verified the assumption that the tangles encountered in these patients were Alzheimer's neurofibrillary tangles. Despite the morphological evidence of Alzheimer's disease, neither of these patients were clinically demented.

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    S. S. Schochet Jr.

  2. Department of Pathology, University of California at San Diego, La Jolla, California

    P. W. Lampert

  3. Division of Neuropathology, Department of Pathology and Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa

    W. F. McCormick

Authors
  1. S. S. Schochet Jr.
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  2. P. W. Lampert
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  3. W. F. McCormick
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Schochet, S.S., Lampert, P.W. & McCormick, W.F. Neurofibrillary tangles in patients with Down's syndrome: A light and electron microscopic study. Acta Neuropathol 23, 342–346 (1973). https://doi.org/10.1007/BF00687465

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  • DOI: https://doi.org/10.1007/BF00687465

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