Skip to main content
Log in

Clinico-pathological correlations in a case of post traumatic pan-hypopituitarism

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

A case of post-traumatic chronic pan-hypopituitarism in a 22 year old man is reported. Post-mortem examination revealed gliosis of the posterior hypothalamus, sclerosis of the neuro-hypophysis, cellular atrophy of the adenohypophysis, with relative hyperplasia of the basophil cells, atrophy of the endocrine target glands. Clinical and morphological findings are correlated and discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Altman, R., Pruzanski, W.: Post-traumatic hypopituitarism. Anterior pituitary insufficiency following skull fracture. Ann. intern. Med.55, 149–154 (1961)

    Google Scholar 

  • Bauer, H. G.: Endocrine and other clinical manifestations of hypothalamic disease. A survey of 60 cases, with autopsies. J. clin. Endocr.14, 13–31 (1954)

    Google Scholar 

  • Beck, E., Daniel, P. M.: Changes in the human hypothalamus after pituitary stalk section or hypophysectomy. J. clin. Path.12, 577 (1959)

    Google Scholar 

  • Castaigne, P., Escourolle, R., Delaporte, P.: Diabète insipide idiopathique. Étude d'une observation anatomo-clinique. Presse méd.78, 999–1001 (1970)

    Google Scholar 

  • Ceballos, R.: Pituitary changes in head trauma (analysis of 102 consecutive cases of head injury). Ala. J. med. Sci.3, 185–198 (1966)

    Google Scholar 

  • Daniel, P. M., Prichard, M. M. L., Treip, C. S.: Traumatic infarction of the anterior lobe of the pituitary gland. Lancet1959 II, 927–930

  • Daniel, P. M., Treip, C. S.: The pathology of the pituitary gland in head injury. In: Modern trends in endocrinology, 2nd ed., pp. 55–68. New York: Hoebner 1961

    Google Scholar 

  • Fontaine, G., Gnamey, D. K., Trannoy, J. M., Farriaux, J. P., Wolter, R., Muller, P. H.: Panhypopituitarisme d'origine hypothalamique secondaire a un traumatisme cranien. Ann. Pédiat.16, 190–198 (1969)

    Google Scholar 

  • Fox, R. H., Davies, T. W., Marsh, F. P., Urich, H.: Hypothermia in a young man with an anterior hypothalamic lesion. Lancet1970 II, 185–188

  • Goldman, K. P., Jacobs, A.: Anterior and posterior pituitary failure after head injury. Brit. med. J.1960 II, 1924–1926

  • Henzi, H.: Zur pathologischen Anatomie des Diabetes insipidus. Mschr. Psychiat. Neurol.123, 292–316 (1952)

    Google Scholar 

  • Klachko, D. M., Winer, N., Burns, T. W., White, J. E.: Traumatic hypopituitarism occurring before puberty: survival 35 years untreated. J. clin. Endocr.28, 1768–1772 (1968)

    Google Scholar 

  • Kornblum, R. N., Fisher, R. S.: Pituitary lesions in craniocerebral injuries. Arch. Path.88, 242–248 (1969)

    Google Scholar 

  • Kotorac, V., Antauer, D.: Diabetes insipidus nach kraniozerebralen Verletzungen. Hefte Unfallheilk.111, 273–277 (1972)

    Google Scholar 

  • Lerman, J., Means, J. H.: Hypopituitarism associated with epilepsy following head injury: report of two cases. J. clin. Endocr.5, 119–131 (1945)

    Google Scholar 

  • Lisser, H., Curtis, L. E.: Treatment of post-traumatic Simmonds' disease with Methyl Testosterone linguets. J. clin. Endocr.5, 363–366 (1945)

    Google Scholar 

  • Mc Cullagh, E. P., Schaffenburg, C. A.: Anterior pituitary insufficiency following skull fracture. Report of a case. J. clin. Endocr.13, 1283–1290 (1953)

    Google Scholar 

  • Porter, R. J., Miller, R. A.: Diabetes insipidus following closed head injury. J. Neurol. Neurosurg. Psychiat.11, 258–262 (1948)

    Google Scholar 

  • Rassmussen, A. T.: The percentage of the different types of cells in the male adult human hypophysis. Amer. J. Path.5, 263–274 (1929)

    Google Scholar 

  • Robertson, J. D., Kirkpatrick, H. F. W.: Simmonds' disease (hypopituitarism) in a man due to traumatic haemorrhage into the pituitary gland. Lancet1951 I, 1048–1051

  • Saphir, O.: Autopsy diagnosis and technic, 4th ed. New York: Hoeber-Harper 1958

    Google Scholar 

  • Treip, C. S.: Hypothalamic lesions in head injury. J. Neurol. Neurosurg. Psychiat.33, 715 (1970)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bevilacqua, G., Fornaciari, G. Clinico-pathological correlations in a case of post traumatic pan-hypopituitarism. Acta Neuropathol 31, 171–177 (1975). https://doi.org/10.1007/BF00688151

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00688151

Key words

Navigation