Summary
The postnatal vascular growth in the cortex of vermis cerebelli folium IX of normal and pre- and postnatally protein-deprived rats was examined. The rate of increase in specific length of vessels seem to parallel the functional maturation of neurons in all cortical layers. From the first postnatal week there is a higher specific length of vessels in the Purkinje cell layer than in the adjoining parts of the molecular and granular layers. The results indicate that such differences are present also after the period of rapid vascular growth. Protein deprivation appears to affect the postnatal increase in specific length of vessels less in the Purkinje cell layer than in the granular and molecular layer where a significant reduction compared to controls was seen for the interval 7–20 days of age. At 90 days of age no significant differences were seen between control and protein-deprived rats.
Similar content being viewed by others
References
Aby, F. S.: Observations on the blood capillaries in the cerebellar cortex of normal young adult domestic cats. J. Comp. Neurol.9, 26–33 (1899)
Alsén, S., Petrén, T.: Die Kapillarisierung der Kleinhirnrinde bei Cavia cobaya. Gegenbaurs Morphol. Jahrb.83, 268–276 (1939)
Altman, J.: Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J. Comp. Neurol.145, 353–398 (1972a)
Altman, J.: Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of purkinje cells and of the molecular layer. J. Comp. Neurol.145, 399–464 (1972b)
Altman, J.: Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer. J. Comp. Neurol.145, 465–514 (1972c)
Barnes, D., Altman, J.: Effects of different schedules of early undernutrition on the preweaning growth of the rat cerebellum. Exp. Neurol.38, 406–419 (1973a)
Barnes, D., Altman, J.: Effects of two levels of gestational-lactational undernutrition on the postweaning growth of the rat cerebellum. Exp. Neurol.38, 420–428 (1973b)
Bär, T., Wolff, J.-R.: Quantitative Beziehungen zwischen der Verzweigungsdichte und Länge von Capillaren im Neocortex der Ratte während der postnatalen Entwicklung. Z. Anat. Entwickl. Gesch.141, 207–221 (1973)
Campbell, A. C. P.: Variation in vascularity and oxidase content in different regions of the brain of the cat. Arch. Neurol. Psychiat. (Chicago)41, 223–242 (1939)
Clos, J., Rebiere, A., Legrand, J.: Differential effects of hypothyroidism and undernutrition on the development of glia in the rat cerebellum. Brain Res.63, 445–449 (1973)
Conighi, R.: Studi sull' angiotectonica dell' encefalo. Rivista sperimentale de freniatria e medicum46, 411–427 (1922)
Conradi, N., Eins, S., Wolff, J.-R.: Postnatal vascular growth in the neocortex of normal and protein-deprived rats. Morphometric studies. Acta Neuropathol. (Berl.)47, 123–130 (1979)
Conradi, N., Engvall, J., Wolff, J.-R.: Angioarchitectonics of rat cerebellar cortex during postnatal development. (in prep.)
Craigie, E. H.: Changes in vascularity in the brain stem and cerebellum of the albino rat between birth and maturity. J. Comp. Neurol.38, 27–48 (1924)
Craigie, E. H.: The comparative anatomy and embryology of the capillary bed of the central nervous system. Proc. Assn. Res. Nerv. Ment. Dis.18, 3–28 (1938)
Dobbing, J., Hopewell, J. W., Lynch, A.: Vulnerability of developing brain: VII. Permanent deficit of neurons in cerebral and cerebellar cortex following early mild undernutrition. Exp. Neurol.32, 439–447 (1971)
Dunning, H. S., Wolff, H. G.: The relative vascularity of various parts of the central and peripheral nervous system of the cat and its relation to function. J. Comp. Neurol.67, 433–450 (1937)
Fazzari, I.: La circolazione arteriosa della corteccia cerebellare. Studio comparative. Rivista di Patologia nervosa e mentale.29, 425–459 (1924)
Fox, C. A., Hillman, D. E., Siegesmund, K. A., Dutta, Ch. R.: The primate cerebellar cortex: A golgi and electron microscopic study. Prog. Brain Res.25, 174–225 (1967)
Friede, R. L.: Die histochemische Reifung des Kleinhirns der Ratte, dargestellt durch das Verhalten der Succinodehydrogenase. Arch. Psychiat. Z. Neurol.196, 196–204 (1957)
Griffin, W. S. T., Woodward, D. J., Chander, R.: Malnutrition and brain development: Cerebellar weight, DNA, RNA, protein and histological correlations. cit. In: Shoemaker and Bloom, 1977 (see below)
Gyllensten, L.: Influence of oxygen exposure on the postnatal vascularization of the cerebral cortex in mice. Acta Morphol. Neerl. Scand.2, 289–310 (1959)
Heinsen, H.: Quantitative anatomical studies on the postnatal development of the cerebellum of the albino rat. Anat. Embryol. (Berl.)151, 201–218 (1977)
Heinsen, N.: Postnatal Quantitative changes in the cerebellar uvula of albino rats. Anat. Embryol. (Berl.)154, 285–304 (1978)
Horstman, H.: Die postnatale Entwicklung der Kapillarisierung im Gehirn eines Nesthockers (Ratte) und eines Nestflüchters (Meerschweinchen). Verh. Anat. Ges.106, 405–410 (1960)
Kissane, J. Q., Hawrylewicz, E. J.: Development of Na+−K+-ATPase in neonatal rat brain synaptosomes after perinatal protein malnutrition. Pediatr. Res.9, 146–150 (1975)
Kornguth, S. E., Scott, G.: The role of climbing fibers in the formation of Purkinje cell dendrites. J. Comp. Neurol.146, 61–82 (1972)
Kuckuk, B.: Über die Entwicklung und Chemodifferenzierung des Kleinhirns der Ratte. Histochemie9, 217–255 (1967)
Larsell, O.: The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J. Comp. Neurol.97, 281–357 (1952)
Manocha, S. L., Olkowski, I.: Experimental protein malnutrition in primates: cytochemical studies on the cerebellum of the squirrel monkey siamiri sciureus. Histochem. J.5, 105–118 (1973)
Neville, H. E., Chase, H. P.: Undernutrition and cerebellar development. Exp. Neurol.33, 485–497 (1971)
Persson, L., Sima, A.: The effect of pre-and postnatal undernutrition on the development of the cerebellar cortex in the rat. II. Histochemical observations. Neurobiology5, 151–166 (1975)
Pfeiffer, R. A.: Grundlegende Untersuchungen für die Angioarchitektonik des menschlichen Gehirns. Berlin: Springer 1930
Pysh, J. J., Perkins, R. E.: Undernutrition and purkinje cell development. Neurosci. Abstr.1, 756 (1975)
Shoemaker, W. J., Bloom, F. E.: Effect of undernutrition on brain morphology. In: Nutrition and the brain, Vol. 2. Wurtman, R. J., Wurtman, J. J. (eds.) New York: Raven Press 1977
Sima, A., Persson, L.: The effect of pre-and postnatal undernutrition on the development of the rat cerebellar cortex. Neurobiology5, 23–34 (1975)
Sobotka, T. J., Cock, M. P., Bradie, R. E.: Neonatal malnutrition: Neurochemical, hormonal, and behavioural manifestations. Brain Res.65, 443–457 (1974)
Uchimura, Y.: Über die Blutversorgung der Kleinhirnrinde und ihre Bedeutung für die Pathologie des Kleinhirns. Z. Gesamte Neurol. Psychiat.120, 774–782 (1929)
Woodward, D. J., Hoffer, B. J., Lapham, L. W.: Postnatal development of electrical and enzyme histochemical activity in purkinje cells. Exp. Neurol.23, 120–139 (1969)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Conradi, N.G., Eins, S. & Wolff, J.R. Postnatal vascular growth in the cerebellar cortex of normal and protein-deprived rats. Acta Neuropathol 47, 131–137 (1979). https://doi.org/10.1007/BF00717036
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00717036