Summary
Cerebral neuroblastoma is a rare neoplasm that has not previously been associated with a phakomatosis. We report a case of an intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease. The neoplasm consisted of process-forming cells containing clear vesicles, dense-cored granules and microtubules. An unusual finding was the presence of intertwining cytoplasmic processes, apparently representing aberrant process formation. We suggest that this case represents a cerebral neuroblastoma occurring as an unusual manifestation of a phakomatosis.
This is a preview of subscription content, log in via an institution to check access.
References
Azzarelli B, Richards DE, Anton AH, Roessmann U (1977) Central neuroblastoma. Electron microscopic observations and catecholamine determinations. J Neuropath Exp Neurol 36:384–397
Chapman RC, Kemp VE, Taleaferro I (1959) Pheochromocytoma associated with multiple neurofibromatosis and intracranial hemangioma. Am J Med 26:883–890
Glushien AS, Mansuy MM, Littman DS (1953) Pheochromocytoma. Its relationship to the neurocutaneous syndromes. Am J Med 14:318–327
Goldammer D, Goebel HH (1980) Dense core vesicles in the desmoplastic variant of cerebral neuroblastoma. Acta Neuropathol (Berl) 50:81–83
Grossman M, Melmon KL (1972) Von Hippel-Lindau disease. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 14, The phakomatoses. Elsevier, New York, pp 241–259
Horten BC, Rubinstein LJ (1976) Primary cerebral neuroblastoma A clinicopathological study of 35 cases. Brain 99:735–756
Melmon KL, Rosen SW (1964) Lindau's disease. Review of the literature and study of a large kindred. Am J Med 36:595–617
Pearl GS, Takei Y (1981) Cerebellar “neuroblastoma”. Nosology as it relates to medulloblastoma. Cancer (in press)
Rhodes RH, Davis RL, Kassel SH, Clague BH (1978) Primary cerebral neuroblastoma: A light and electron microscopic study. Acta Neuropathol (Berl) 41:119–124
Shin WY, Laufer H, Lee YC, Aftalion B, Hirano A, Zimmerman HM (1978) Fine structure of a cerebellar neuroblastoma. Acta Neuropathol (Berl) 42:11–13
Ts'o MOM, Fine BS, Zimmerman LE (1969) The Flexner-Wintersteiner rosettes in retinoblastoma. Arch Path 88:664–671
Wolf A, Wilens SL (1934) Multiple hemangioblastomas of the spinal cord with syringomyelia. A case of Lindau's disease. Am J Path 10:545–568
Yagishita S, Itoh Y, Chiba Y, Yuda K (1978) Cerebral neuroblastoma. Virch Arch A (Path Anat) 381:1–11
Yagishita S, Itoh Y, Chiba Y, Yamashita T, Nakazima F, Kuwabara T (1980) Cerebellar neuroblastoma. A light and ultrastructural study. Acta Neuropathol (Berl) 50:139–142
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pearl, G.S., Takei, Y., Stefanis, G.S. et al. Intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease. Acta Neuropathol 53, 253–256 (1981). https://doi.org/10.1007/BF00688029
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688029