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The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate

I. Superficial venous system. A quantitative analysis

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Summary

The angiogenesis of the rat cerebrum was studied under pathologic conditions caused by the administration of the neurotoxin methylazoxymethanol acetate (MAMAc) in the time (E14) of neuroblast migration. The sinovenous junction of the main superficial cerebral veins and the morphological changes of the veins were examined by a quantitative analytic method. The hypoplastic areas of the brains showed extremely malformed venous systems with pathologic changes of the sinovenous junctions depending on the degree of disturbance of the neuroblast migration. These findings suggest the primary role of the neuronal maturation in the angioarchitectonic development and the direct dependency of the vascular differentiation on the neuroblast migration of the drained territory.

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Authors and Affiliations

  1. Dept. of Neuropathology, University of Göttingen, Robert-Koch-Straße 40, D-3400, Göttingen, Federal Republic of Germany

    A. Bardosi & R. L. Friede

  2. Nept. of Neurosurgery, University of Göttingen, Robert-Koch-Straße 40, D-3400, Göttingen, Federal Republic of Germany

    G. Ambach

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  1. A. Bardosi
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  2. G. Ambach
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  3. R. L. Friede
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Supported in part by the Alexander-von-Humboldt-Foundation

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Bardosi, A., Ambach, G. & Friede, R.L. The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate. Acta Neuropathol 66, 253–263 (1985). https://doi.org/10.1007/BF00688591

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  • DOI: https://doi.org/10.1007/BF00688591

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