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Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system: an immunohistochemical investigation

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Summary

This report deals with the expression of stress-response (heat-shock) protein 72 (srp 72) in a series of 95 primary human brain tumors and 21 carcinoma metastases to the central nervous system (CNS). Immunohistochemical procedures were employed; cells of the human cervical cancer line HeLa S3 were used as positive controls. The protein was detected in 14/22 meningiomas and in 6/13 glioblastomas. Tumor cells expressing srp 72 were also found in 4/17 astrocytomas, 2/9 pituitary tumors, 2/14 primitive neuroectodermal tumors and 1/10 medulloblastomas. Whereas the majority (8/10) of the breast carcinoma metastases had tumor cells that expressed srp 72, only 2/11 lung tumor metastases were positively stained. These results document srp 72 expression by a variety of primary and metastatic tumors of the CNS.

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Authors and Affiliations

  1. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA

    S. Kato & A. Hirano

  2. Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA

    M. Kato & F. Herz

  3. Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 683, Yonago, Japan

    E. Ohama

Authors
  1. S. Kato
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  2. A. Hirano
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  3. M. Kato
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  4. F. Herz
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  5. E. Ohama
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Supported in part by NIH grant CA47512 (to FH)

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Kato, S., Hirano, A., Kato, M. et al. Stress-response (heat-shock) protein 72 expression in tumors of the central nervous system: an immunohistochemical investigation. Acta Neuropathol 84, 261–264 (1992). https://doi.org/10.1007/BF00227818

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  • DOI: https://doi.org/10.1007/BF00227818

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