Abstract
Intracytoplasmic inclusion bodies are rarely found in meningiomas. A 74-year-old woman had an anaplastic meningioma with intracytoplasmic chromophobe inclusion bodies (CIB) histologically. These CIB were various shapes, e.g. round, teardrop-like, fusiform, horseshoe-like, crescentic and perinuclear. The size of CIB ranged from 7 to 14 μm and the nuclei of the tumor cells with CIB were often eccentric. Most CIB were immunopositive only for vimentin, staining more intensely than surrounding cytoplasm in a comparative study using adjacent sections stained with hematoxylin-eosin and vimentin. CIB showed loosely textured filamentous structures which were in parallel and entangled arrangements ultrastructurally. The diameter of the filaments was 13–14 nm and they were thicker than normal intermediate filaments. Moreover, these filaments appeared to be studded with granular and fuzzy substances. These findings suggest that CIB are mainly composed of abnormally synthesized and arranged vimentin filaments.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 1 July 1996 / Revised: 20 September 1996 / Accepted: 27 September 1996
Rights and permissions
About this article
Cite this article
Saito, A., Nakazato, Y., Hirato, J. et al. Intracytoplasmic chromophobe inclusion bodies in an anaplastic meningioma. Acta Neuropathol 93, 421–425 (1997). https://doi.org/10.1007/s004010050634
Issue Date:
DOI: https://doi.org/10.1007/s004010050634