Summary
Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days. The treated animals showed the same per cent weight gain as the controls. The total hydroxyproline content of the skin and the hydroxyproline content in different collagen fractions was the same in treated and untreated animals. Thus fluocortolone seems to have no specific effect on the synthesis or the breakdown of collagen in the guinea pig skin. Also the physical development of the animals, kept under defined conditions, failed to show a catabolic effect of fluorcortolone.
Zusammenfassung
Spezifisch pathogenfreie Meerschweinchen wurden 15 Tage lang mit verschiedenen Dosen Fluocortolon behandelt. Die behandelten Tiere zeigten die gleiche prozentuale Gewichtszunahme wie die Kontrolltiere. Der Gesamt-Hydroxyprolingehalt der Haut war in beiden Gruppen gleich, ebenso der Hydroxyprolingehalt in verschiedenen Kollagenfraktionen. Mithin scheint Fluocortolon keinen spezifischen Effekt auf die Synthese oder den Abbau von Kollagen in der Meerschweinchenhaut zu haben. Auch in der Gewichtsentwicklung der unter definierten Tierstallbedingungen gehaltenen Tiere zeigte sich kein kataboler Effekt des Fluocortolons.
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Wepler, R., Burkhardt, H. & Rommel, K. The influence of fluocortolone treatment on the collagen content in guinea pig skin. Arch. Derm. Res. 257, 287–292 (1977). https://doi.org/10.1007/BF00741845
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DOI: https://doi.org/10.1007/BF00741845