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Histochemische und elektronenmikroskopische Untersuchungen am Histiocytom

Histochemical and electron microscopical studies of histiocytoma

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Summary

In histiocytomas the alkaline phosphatase technique reveals a surprising number of capillaries. The capillaries branch out from the center to the periphery of the histiocytoma and even the capillaries beneath the epidermis proliferate. The cellular elements outside the capillaries, however, are fibroblasts, histiocytes and mast cells, as is revealed by various histochemical and electron microscopical examinations. Histiocytomas of short duration differ from older histiocytomas in that the former contain fibroblasts similar to those found in healing wounds (C-fibroblasts).

Zusammenfassung

Überprüft man in Histiocytomen mit Hilfe des Nachweises der alkalischen Phosphatase den Verlauf der Capillaren, so überrascht die große Zahl der Gefäße. Von einem Zentrum erstrecken sich diese durch das ganze Histiocytom, selbst die über dem Histiocytom unter der Epidermis gelegenen Capillaren sind gewuchert.

Histochemische und elektronenmikroskopische Untersuchungen zeigen aber, daß die Mehrzahl der Tumorzellen keine Gefäßzellen sind, sondern Fibroblasten, Histiocyten und Mastzellen. Die jüngeren Fibroblasten gleichen Elementen, die man auch bei der Wundheilung findet und die man als C-Fibroblasten bezeichnet hat.

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Literatur

  1. Auböck L (1975) Zur Ultrastruktur fibröser und histiocytärer Hauttumoren (Dermatofibroma, Dermatofibrosarcoma protuberans, Fibroxanthom und Histiocytom). Virchows Arch Abtl A 368:253–274

    Google Scholar 

  2. Bauer PS, Barratt G, Linares HA, Dubrovszky M, Houssaye AJ de la, Larson DL (1978) Wound contraction, scar contractures and myofibroblasts: a classical case study. J Trauma 18:8–22

    Google Scholar 

  3. Bouissou H, Pieraggi MTh, Julian M (1971) Le fibroblaste cutané au cours du vieillis sement et de certains états pathologiques. Ann Anat Pathol 16:373–386

    Google Scholar 

  4. Breathnach J, Curchill A (1971) An atlas of the ultrastructure of human skin. London

  5. Burstone MS (1960) Histochemical demonstration of cytochrome oxidase with new amine reagents. J Histochem Cytochem 8:63–70

    Google Scholar 

  6. Burstone MS (1961) Histochemical demonstration of phosphatases in frozen sections with Naphthol-AS-Phosphatases. J Histochem Cytochem 9:146–153

    Google Scholar 

  7. Davies BJ, Ornstein L (1959) High resolution enzym localization with a new diazo reagent “hexazonium pararosanilin”. J Histochem. Cytochem 7:297–298

    Google Scholar 

  8. Fisher ER, Vuzevski V (1967) Cytogenesis of schwannoma (neurilemoma), neurofibroma, dermatofibroma and dermatofibrosarcoma as revealed by electron microscopy. Am J. Clin Pathol 49:141–154

    Google Scholar 

  9. Frenk E (1961) Zur Histologie der Fibrome und Histiocytome der Haut. Hautarzt 12:15–19

    Google Scholar 

  10. Gabbiani GG, Ryan B, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549–550

    Google Scholar 

  11. Gabbiani G, Hirschel GJ, Ryan GB, Statkov PR, Majno G (1972) Granulation tissue as a contractile organ. Exp Med 135:719–734

    Google Scholar 

  12. Glenner GG, Burstone MS, Meyer DB (1959) A study of aminopeptidase activity in the stroma of neoplastic tissue, with a comparison of histochemical techniques. J Nat Cancer Inst 23:857–874

    Google Scholar 

  13. Gomori G (1952) The histochemistry of esterases. Int Rev Cytol 1:323–335

    Google Scholar 

  14. Katenkamp D, Stiller D (1975) Cellular composition of the socalled dermatofibroma (Histiocytoma cutis). Virchows Arch A Pathol Anat Histol 367:325–336

    Google Scholar 

  15. Katenkamp D, Stiller D, Schulze E (1976) Ultrastructural cytology of regenerating tendon. An experimental study. Exp Pathol 12:25–37

    Google Scholar 

  16. Kleinhans D (1975) Enzymhistochemische und feulgencytophotometrische Untersuchung an Zellen des Hautbindegewebes bei Entzündung und Geschwulstwachstum. Z Hautkr, Suppl. 1 1:47

    Google Scholar 

  17. Leder LD (1964) Über die selective fermentcytochemische Darstellung von neutrophilen myelotischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wochenschr 42:553

    Google Scholar 

  18. Lever WF, Schaumburg-Lever G (1975) Histopathology of the skin. Lippincott Co, Philadelphia

    Google Scholar 

  19. Mihatsch-Konz B, Schaumburg-Lever G, Lever WF (1973) Ultrastructure of dermatofibroma. Arch Dermatol Forsch 246:181–192

    Google Scholar 

  20. Moloney WC, McPherson K, Fliegelman L (1960) Esterase activity in leucocytes demonstrated by use of naphthol-AS-D-chloracetat substrate. J Histochem 8:200–207

    Google Scholar 

  21. Montadon D, Gabbiani G, Ryan GB, Majno G (1973) The contractile fibroblast. Its relevance in plastic surgery. Plastic Reconstr Surg 52:286–290

    Google Scholar 

  22. Nachlas MM, Seligman AM (1949) The comparative distribution of esterase in the tissues of five mammals by histochemical technique. Anat Rec 105:677–695

    Google Scholar 

  23. Nachlas MM, Crawford DT, Silvermann RM (1960) Improvement in the histochemical localisations of leucin-aminopeptidase with a new substrate, L-leucyl-4-methoxy-2-naphthylamide. J Biophys Biochem Cytol 7:261–264

    Google Scholar 

  24. Niemi KM (1970) The benign histiocytic tumors of the skin. Acta Derm Venereol (Stockh) 50: Suppl 63

  25. Nishiyama S (1970) Capillardarstellung durch die alkalische Phosphatase-Färbung bei verschiedenen Dermatosen. VIII. Dermato-mesenchymale Tumoren. Hautarzt 15:381–390

    Google Scholar 

  26. Nödl F (1960) Histiocytome. In: Gottron-Schönfeld (Hrsg) Dermatologie und Vererologie, Bd I, S 209–211

  27. Papadimitriou JM, Spector WG (1972) The ultrastructure of high-, and low-turnover inflammatory granulomata. J Pathol 106:37–43

    Google Scholar 

  28. Pearse AGE (1968) Theoretical and applied histochemistry. Churchill Ltd., London, p 731

    Google Scholar 

  29. Ross R, Greenlee TK Jr (1966) Electron microscopy: attachment sites between connective tissue cells. Science 153:997–999

    Google Scholar 

  30. Rentiers PL, Montgomery (1949) Nodular subepidermal fibrosis (Dermatofibroma versus Histiocytoma). Arch Dermatol (Chic) 59:568–583

    Google Scholar 

  31. Schaefer HE, Fischer R (1968) Eine spezifische Färbung eosinophiler Granulocyten mit Biebricher Scharlach. Klin Wochenschr 46:396–397

    Google Scholar 

  32. Schaefer HE, Fischer R (1968) Der Peroxydasenachweis an Ausstrichpräparaten sowie an Gewebsschnitten nach Entkalkung und Paraffineinbettung. Klin Wochenschr 46:1228–1320

    Google Scholar 

  33. Schaefer HE (1978) persönliche Mitteilung

  34. Schellander F, Marks R (1973) Tissue interrelationships in cutaneous granulomata. Br J Dermatol 89:537–542

    Google Scholar 

  35. Schoefl G (1963) Studies of inflammation III. Growing capillaries: their structure and permeability. Virchows Arch Pathol Anat 337:97–141

    Google Scholar 

  36. Senear FE, Caro MR (1936) Histiocytoma cutis. Arch Derm (Chic) 33:209–226

    Google Scholar 

  37. Spector WG (1971) The cellular dynamics of granulomas. Proc Roy Soc Med 64:941–942

    Google Scholar 

  38. Steigleder GK (1967) Verhalten der Epidermis über Histiocytomen bei akutem psoriatischen Schub (Mit Beobachtungen zur Struktur der Histiocytome, im besonderen über das Verhalten der Mastzellen). Hautarzt 18:216–218

    Google Scholar 

  39. Wigger JH, Mitsudo SM (1976) Fibrous histiocytoma simulating congenital fibromatosis. Virchows Arch A Pathol Anat Histol 370:255–266

    Google Scholar 

  40. Woringer F, Kwiatkoski S (1932) L'histiocytome de la peau. Ann Dermatol 3:998–1010

    Google Scholar 

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Authors and Affiliations

  1. Universitäts-Hautklinik Köln (Direktor: Prof. Dr. G. K. Steigleder), Josef-Stelzmann-Straße 9, D-5000, Köln 41, Bundesrepublik Deutschland

    A. Galosi & G. K. Steigleder

  2. Universitäts-Hautklinik Szeged (Direktor: Prof. Dr. M. Simon), Szeged, Ungarn

    I. Schneider

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  1. I. Schneider
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  2. A. Galosi
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  3. G. K. Steigleder
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Hautklinik in Szombathely (Chefarzt: Doz. Dr. I. Schneider), Szombathely, Ungarn

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Schneider, I., Galosi, A. & Steigleder, G.K. Histochemische und elektronenmikroskopische Untersuchungen am Histiocytom. Arch Dermatol Res 267, 47–60 (1980). https://doi.org/10.1007/BF00416921

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  • DOI: https://doi.org/10.1007/BF00416921

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