Summary
Using a combination of immunohistochemistry and planimetric observation we report the density and distribution of Langerhans cells (LCs) in epithelium from the normal ectocervix and from the normal transformation zone (TZ). The density of LCs increased towards the basement membrane. Dendritic LCs aspect was more prominent in the superficial layers.
Similar content being viewed by others
References
Alberico S, Casaccia R, Facca MC, Di Bonito L, Mandruzzato G (1989) Langerhans cells in the uterine cervix. The Cervix 7:201–205
Ashwort J, Turbitt ML, Mackie R (1986) The distribution and quantification of the Langerhans cell in normal human epidermis. Clin Exp Dermatol 11:153–158
Bos DJ, Kapsenberg ML (1986) The skin immune system. Immunol Today 7:235–240
Breathnach SM (1988) The Langerhans cell. Br J Dermatol 119:463–469
Caorsi I, Figueroa CD (1986) Langerhans cell density in the normal exocervical epithelium and in the cervical intraepithelial neoplasia. Br J Obstet Gynaecol 93:993–998
Cattoretti G, Berti E, Mancuso A (1986) An MHC class I related family of antigens with widespread distribution on resting and activated cells. In: McMichael J, Beverley CL, Cobbold S et al. (eds) Leukocyte Typing III, Oxford University, p 89
Edwards JN, Morris HHB (1985) Langerhans cells and lymphocyte subsets in the female genital tract. Br J Obstet Gynaecol 92:974–982
Elbe A, Tschachler E, Steiner G, Binder A, Wolff K, Stingl G (1989) Maturational steps of bone marrow-derived dendritic murine epidermal cells. J Immunol 143:2431–2438
Figueroa CD, Caorsi I (1980) Ultraestructural and morphometric study of the Langerhans cell in the normal human exocervix. J Anat 131:669–682
Hachisuga T, Fukuda K, Hayashi Y, Iwasaka T, Sugimori H (1989) Immunohistochemical demonstration of histiocytes in normal ectocervical epithelium and epithelial lesions of the uterine cervix. Gynecol Oncol 33:273–278
Hawthorn RJS, MacLean AB (1987) Langerhans cell density in the normal exocervical epithelium and in the cervical intraepithelial neoplasia. Br J Obstet Gynaecol 94:815–816
Hawthorn RJ, Murdoch JB, MacLean AB, MacKie RM (1988) Langerhans cells and subtypes of human papillomavirus in cervical intraepithelial neoplasia. Br Med J 297:643–646
Katz SI (1985) The skin as an immunologic organ. J Am Acad Dermatol 13:530–536
King PD, Katz DR (1990) Mechanisms of dendritic cell function. Immunol Today 11:206–211
Mackenzie IC, Squier CA (1975) Cytochemical identification of ATPasa-positive Langerhans cells in EDTA-separated sheets of normal epidermis. Br J Dermatol 92:523–533
McArdle JP, Muller K (1986) Quantitative assessment of Langerhans cells in human cervical intraepithelial neoplasia and wart virus infection. Am J Obstet Gynecol 154:509–515
Melief CJM (1989) Dendritic cells as specialized antigen-presenting cells. Res Immunol 140:877–926
Morris HHB, Gatter KC, Stein H, Mason DY (1983) Langerhans cells in human cervical epithelium: an immunohistological study. Br J Obstet Gynaecol 90:400–411
Morris HHB, Gatter KC, Sykes G, Casemore V, Mason DY (1983) Langerhans cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia. Br J Obstet Gynaecol 90:412–420
Scaletta LJ, MacCallum DK (1972) A fine structural study of divalent cation-mediated epithelial union with connective tissue in human oral mucosa. Am J Anat 133:431–438
Tay SK, Jenkins D, Maddox P, Campion M, Singer A (1987) Subpopulations of Langerhans cells in cervical neoplasia. Br J Obstet Gynaecol 94:10–15
Vayrynen M, Syrjanen K, Mantyjarvi R, Castren O, Saarikoski S (1984) Langerhans cells in human papillomavirus (HPV) lesions of the uterine cervix identified by the monoclonal antibody OKT6. Int J Gynaecol Obstet 22:375–383
Younes MS, Robertson EM, Bencosme SA (1968) Electron microscope observations on Langerhans cells in the cervix. Am J Obstet Gynecol 102:397–403
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morelli, A.E., di Paola, G. & Fainboim, L. Density and distribution of Langerhans cells in the human uterine cervix. Arch Gynecol Obstet 252, 65–71 (1992). https://doi.org/10.1007/BF02389630
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02389630