Summary
We examined the nasal responsiveness to topical methacholine application in allergic rhinitis and non-allergic chronic rhinitis patients, and in control subjects. Methacholine responsiveness was significantly higher in allergic rhinitis patients than in non-allergic patients and control subjects. In perennial rhinitis, methacholine responsiveness correlated with the severity of daily nasal symptoms and those provoked by specific allergen challenge tests. Among nasal symptoms, hyper-rhinorrhoea was found to be closely related to methacholine responsiveness. As a result of these findings, the possibility of cholinergic hyper-reactivity in allergic rhinitis patients is discussed.
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Asakura, K., Enomoto, K., Ara, H. et al. Nasal responsiveness to methacholine stimulation in allergic rhinitis patients. Arch Otorhinolaryngol 239, 273–278 (1984). https://doi.org/10.1007/BF00464255
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DOI: https://doi.org/10.1007/BF00464255