Simultanes Wachstum von Carcinom und Präcancerose im Kehlkopf — eine stratigraphische histomorphologische Analyse

Summary

Chronic and diffuse contact between inhalation noxae and the mucosa plays an important role in the pathogenesis of cancer of the larynx and lead us to expect a multilocular development of carcinoma and precancerous changes. This supposition was examined in some 100 larynx resection preparations.

After standardized stratigraphic sub-divisioning of the larynx, it was lamellated and the individual zones studied histologically for epithelial dysplasias, varying degrees of differentation up to an including carcinoma, and for inflammatory changes.

Certain relationships were found to exist between certain characteristics of growth of the carcinoma and the site, extent and histological classification of the tumour. The fact that, frequently, a macroscopically non-verifiable coexistance of precancer and carcinoma can be found, is taken account of in the modified conception for the taking of biopsies.