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Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster

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Abstract

Studies on Feulgen-DNA content in the polytene chromosomes of D. melanogaster T(1∶4)w m258-21 heterozygotes showed that when the euchromatic region 3D1-E2 is located next to the heterochromatic breakpoint it contains less DNA than in the non-translocated homologue (Hartmann-Goldstein and Cowell, 1976). In contrast to the region adjacent to the breakpoint, region 3C1–10, which contains intercalary heterochromatin, shows more DNA in the translocated than in the non-translocated chromosome. Transposition may induce morphologically euchromatic regions containing putatively underreplicated sequences to undergo additional replication cycles. Region 2E1-3A4, distal to 3C1 and at some distance from the heterochromatic breakpoint is apparently unaffected. Extended replication and reduced DNA content in regions which have undergone chromosomal rearrangement could be accounted for by varying degrees of blockage of replication in individual strands of the polytene chromosome.

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Author notes

  1. J. K. Cowell

    Present address: Department of Cellular Pathology, Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX, London, England

Authors and Affiliations

  1. Department of Genetics, University of Sheffield, S10 2TN, Sheffield, England

    J. K. Cowell & I. J. Hartmann-Goldstein

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  1. J. K. Cowell
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  2. I. J. Hartmann-Goldstein
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Cowell, J.K., Hartmann-Goldstein, I.J. Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster . Chromosoma 79, 329–340 (1980). https://doi.org/10.1007/BF00327323

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  • DOI: https://doi.org/10.1007/BF00327323

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