Summary
The disorganizing process of glomerular lesions in a Wegener's granulomatosis was analyzed. Intracapillary damage of mesangial disintegration (mesangiolysis) was followed by extracapillary extension of the injury (crescent formation and granulomatous reaction) in which a rupture of the glomerular basement membrane was observed.
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References
Altmann, H. W., Schicke, H.: Ein Beitrag zur Histologie und zur Einordnung der Wegenerschen Granulomatose. Beitr. path. Anat. 121, 211–241 (1959)
Anthony, S. F., Wolff, S. M.: Wegener's granulomatosis: Studies in eighteen patients and a review of the literature. Medicine (Baltimore) 52, 532–561 (1973)
Godman, G. C., Churg, J.: Wegener's granulomatosis. Pathology and review of the literature. Arch. Path. 58, 533–553 (1954)
Kobayashi, Y., Shigematsu, H.: Rapidly progressive glomerulonephritis in rabbit serum sickness. Excerpta Medica, Internat, congress series 300, 68 (1973)
Kondo, Y., Shigematsu, H., Kobayashi, Y.: Cellular aspects of rabbit Masugi nephritis. II. Progressive glomerular injuries with crescent formation. Lab. Invest. 27, 620–631 (1972)
Morita, T., Suzuki, Y., Churg, J.: Structur e and development of the glomerular crescent. Amer. J. Path. 72, 349–368 (1973)
Okabayashi, A.: Nephritides and dysimmunization; with special reference to the significance of lytic process in immunologically induced experimental glomerulonephritis. Jap. J. Nephrol. 12, 1–17 (1970)
Shigematsu, H., Shishido, H., Kuhara, K., Tsuchida, H., Suzuki, H., Hirose, K., Tojo, S.: Participation of monocytes in transient glomerular hypercellularity in poststreptococcal glomerulonephritis. Virchows Arch. Abt. B 12, 367–370 (1973)
Shigematsu, H., Kobayashi, Y.: The distortion and disorganization of the glomerulus in progressive Masugi nephritis in the rat. Virchows Arch. Abt. B 14, 313–328 (1973)
Stejskal, J., Pirani, C. L., Okada, M., Mandelnakis, N., Pollak, V. E.: Discontinuities (gaps) of the glomerular capillary wall and basement membrane in renal diseases. Lab. Invest. 28, 149–169 (1973)
Suzuki, Y., Churg, J., Grishman, E., Mautner, W., Dach, S.: The mesangium of renal glomerulus. Amer. J. Path. 43, 555–578 (1963)
Wegener, F.: Über eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems und der Nieren. Beitr. path. Anat. 102, 36–68 (1939)
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The authors wish to acknowledge Mr. T. Yamada for his technical assistance and Mr. Gertz for the preparation of English manuscript.
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Shigematsu, H., Ohtsu, H. & Matsuba, M. Segmental disorganizing glomerulonephritis in a Wegener's granulomatosis. Virchows Arch. A Path. Anat. and Histol. 363, 359–362 (1974). https://doi.org/10.1007/BF00447846
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DOI: https://doi.org/10.1007/BF00447846