Summary
The process of quantification has led pathology into an objective and abstract direction to which it is unaccustomed. The introduction of the concept of homology in pathology by Doerr has proven to be very fruitful, since it has helped to clarify otherwise poorly understood relationships. As shown in the foregoing paper, the succes of the homology concept applies also to quantitative organelle pathology. Homologies have demonstrated relationships within the ergastoplasmic — mitochondrial — peroxisomal system which are apparent only with the help of symbolic logic. These homologies permit inferences, shown here with the example of glycogenosis type I, regarding the adaptive potential of the cell and the degree of cellular damage. In addition, these homologies, which are described in terms of formal logic, may serve as a model for human pathologic anatomy.
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Supported by Grant Ri 271/5 from the Deutsche Forschungsgemeinschaft, West Germany. Dr. Moore is a Research Fellow of the American Heart Association Maryland Affiliate, Inc., USA
We are extremely grateful to Prof. Dr. R. Gitzelmann and Doz. Dr. M. Spycher for providing the biopsy material.
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Riede, U.N., Moore, G.W. The concept of homology in quantitative organelle pathology. Virchows Arch. A Path. Anat. and Histol. 389, 225–240 (1980). https://doi.org/10.1007/BF00439488
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DOI: https://doi.org/10.1007/BF00439488