Summary
During studies of the antigenic and functional properties of hepatic sinusoidal lining cells in situ, we found that only the sinusoidal endothelial cells share antigens with a peripheral blood macrophage subset capable of presenting soluble antigens and triggering autologous mixed lymphocyte reactions. They were HLA-DR+, OKM1−, OKM5+. Vascular endothelial cells in the portal areas and central veins were HLA-DR+, OKM1− and OKM5−. The sinusoidal endothelial cells also expressed an antigen found on helper/inducer (OKT4 and Leu3 a) T lymphocytes. Thus, the present study suggests that endothelial cells in different anatomic compartments in the liver heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes and possess distinct immunological functions.
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Nagura, H., Koshikawa, T., Fukuda, Y. et al. Hepatic vascular endothelial cells heterogenously express surface antigens associated with monocytes, macrophages and T lymphocytes. Vichows Archiv A Pathol Anat 409, 407–416 (1986). https://doi.org/10.1007/BF00705413
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DOI: https://doi.org/10.1007/BF00705413