Summary
Immunohistochemical studies on synovial sarcomas have proved the potentiality of these neoplasm for epithelial and mesenchymal differentiation and antibodies detecting epithelial cells have been found to be helpful in determining the histological types. In this study different epithelial markers directed against various cytokeratins, HMFG-2 and EMA were investigated on paraffin embedded tissues of 13 cases of synovial sarcomas, with regard to their reliability in unmasking the epithelial components demonstrable in this type of neoplasm. The results lead to three conclusions firstly, synovial sarcomas possess the capacity for generating different epithelial cell types with uncommon compositions of intermediate filaments as well as of membrane proteins, secondly, these features may be expressed in a heterogenous pattern even within the same tumour and finally, the use of wide range anti-cytokeratin antibodies covering the spectrum of basic as well as acidic type proteins seems to be necessary for the detection of all epithelial components demonstrable in synovial sarcomas.
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Abenoza P, Manivel JC, Swanson PE, Wick MR (1986) Synovial sarcoma: Ultrastructural study and immunohistochemical analysis by a combined peroxidase-antiperoxidase/Avidin-Biotin-peroxidase complex procedure. Hum Pathol 17:1107–1115
Cadman NL, Soule EH, Kelly PJ (1965) Synovial sarcoma: An analysis of 134 tumors. Cancer 18:613–627
Corson JM, Weiss LM, Banks-Schlegel S, Pinkus GS (1983) Keratin proteins in synovial sarcoma. Am J Surg Pathol 7:107–109
Enzinger FM, Weiss SW (1988) Soft tissue tumors. Second edition; The C.V. Mosby Comp, St Louis, pp 659–688
Franke WW, Winter S, von Overbeck J, Gudat F, Heitz PU, Strähli C (1987) Identification of the conserved, conformation-dependent cytokeratin epitope recognized by monoclonal antibody (lu-5). Virchows Arch [A] 411:137–147
Fuchs E (1988) Keratins as biochemical markers of epithelial differentiation. TIG 4:277–281
Haagensen CD, Stout AP (1944) Synovial sarcoma. Ann Surg 120:826–842
Hajdu SI, Shiu MH, Fortner JG (1977) Tenosynovial sarcoma: A clinocopathological study of 136 cases. Cancer 39:1201–1217
Leader M, Patel J, Collins M, Kristin H (1987) Synovial sarcomas. True carcinosarcomas? Cancer 59:2096–2098
Mackenzie DH (1966) Synovial sarcoma: A review of 58 cases. Cancer 19:1669–1680
Mackenzie DH (1977) Monophasic synovial sarcoma: a histological entity? Histopathology 1:151–157
Mason DJ, Naiem M, Abulaziz Z, Nash JRG, Gatter KG, Stein H (1982) Immunohistochemical labeling of cryostat sections with monoclonal antibody. In: McMichael AJ, Fabre JW (eds) Monoclonal antibodies in clinical medicine. Acadmic Press, London, pp 632–635
Miettinen M, Lehto V-P, Virtanen I (1982) Keratin in the epithelial-like cells of classical biphasic synovial sarcoma. Virchows Arch [B] 40:157–161
Miettinen M, Lehto V-P, Virtanen I (1983) Monophasic synovial sarcoma of spindle cell type: epithelial differentiation as revealed by ultrastructural features, content of prekeratin and binding of peanut agglutinin. Virchows Arch [B] 44:187–199
Moll R, Franke WW, Geiger B, Krepler R, Schiller DL (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11–24
Moll R, Achtstätter T, Brecht E, Balcarova-Ständer J, Ittensohn M, Franke WW (1988) Cytokeratins in normal and malignant transitional epithelium. Am J Pathol 132:123–144
Mukai M, Torikata C, Iri H, Mikata A, Kawai T, Hanaoka H, Yakumaru K, Kageyama K (1984) Histogenesis of clear cell sarcoma of tendons and aponeuroses: An electron-microscopic, biochemical, enzyme histochemical, and immunohistochemical study. Am J Pathol 114:264–272
Sternberger LA (1974) The unlabeled antibody enzyme method. Immunohistochemistry. Prentice Hall, Englewood Cliff NJ, pp 129–171
Wrba F, Ritzinger E, Reiner A, Holzner JH (1987) Die Aussagekraft und prognostische Bedeutung von Alpha-Laktalbumin (ALA), Laktoferrin (Lfr) und HMFG-2 in primären Mammakarzinomen. Pathologe 8:25–30
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Wrba, F., Fertl, H., Amann, G. et al. Epithelial markers in synovial sarcoma. Vichows Archiv A Pathol Anat 415, 253–258 (1989). https://doi.org/10.1007/BF00724912
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DOI: https://doi.org/10.1007/BF00724912