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Granular cell tumour of the breast

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Summary

Eight cases of benign granular cell tumour of the breast are reported. Seven patients were women and one was male. The age at the time of the excision ranged from 17 to 73 (average 40.1) years. All tumours were positive for S-100 protein and negative for keratin, myoglobin and gross cystic disease fluid protein. In two cases ultrastructural studies revealed findings identical to those in the previously reported cases of granular cell tumours. None of these cases were diagnosed preoperatively. In six cases the clinical and mammographic findings, and in one case the frozen section, led to an erroneous diagnosis of malignancy. The clinico-pathological features of the cases are delineated in order to draw attention to a benign condition which closely simulates malignancy.

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Authors and Affiliations

  1. Istituto di Anatomia e Istologia Patologica, Università di Bologna, Ospedale Bellaria, via Altura 3, I-40139, Bologna, Italy

    Stefania Damiani & Vincenzo Eusebi

  2. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Frederick C. Koerner & G. Richard Dickersin

  3. Department of Pathology, Royal Surrey County Hospital, Guildford, UK

    Martin G. Cook

Authors
  1. Stefania Damiani
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  2. Frederick C. Koerner
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  3. G. Richard Dickersin
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  4. Martin G. Cook
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  5. Vincenzo Eusebi
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Damiani, S., Koerner, F.C., Dickersin, G.R. et al. Granular cell tumour of the breast. Vichows Archiv A Pathol Anat 420, 219–226 (1992). https://doi.org/10.1007/BF01600274

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  • DOI: https://doi.org/10.1007/BF01600274

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