Summary
Malignant rhabdoid tumours (MRTs) are highly aggressive neoplasms which most frequently occur in the kidney of young children. Several cases of primary MRT occurring in extra-renal sites have been reported, particularly in the soft tissues. We report a case of primary MRT of the uterus, a very rare site for this neoplasm, with morphological, immunohistochemical and ultrastructural features corresponding to restrictive morphological criteria for MRT. The possible differential diagnoses were considered.
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Akhtar M, Kim PY, Young I (1975) Ultrastructure of endometrial stromal sarcoma. Cancer 35:406–412
Balaton AJ, Vaury P, Videgrain M (1987) Paravertebral malignant rhabdoid tumor in an adult. Pathol Res Pract 182:713–716
Blatt J, Russo P, Taylor S (1986) Extrarenal rhabdoid sarcoma. Med Pediatr Oncol 14:221–226
Carter RL, McCarty KP, Alsam SZ, Monaghan P, Agrawal M, McElwain TJ (1989) Malignant rhabdoid tumour of the bladder with immunohistochemical and ultrastructural evidence suggesting histiocytic origin. Histopathology 14:179–190
Cho KR, Rosenshein NB, Epstein JI (1989) Malignant rhabdoid tumor of the uterus. Int J Gynecol Pathol 8:381–387
Dabbs DJ, Park HK (1988) Malignant rhabdoid skin tumour: an uncommon primary skin neoplasm. Ultrastructural and immunohistochemical analysis. J Cutan Pathol 15:109–115
Dervan PA, Cahalane SF, Kneafsey P, Mynes A, McAllister K (1987) Malignant rhabdoid tumour of soft tissue. An ultrastructural and immunohistological study of a pelvic tumour. Histopathology 11:183–190
Devaney K, Tavassoli FA (1991) Immunohistochemistry as a diagnostic aid in the interpretation of unusual mesenchymal tumors of the uterus. Mod Pathol 4:225–231
Doglioni C, Dell'Orto P, Coggi G, Iuzzolino P, Bontempini L, Viale G (1987) Choroid plexus tumors. An immunocytochemical study with particular reference to the coexpression of intermediate filament proteins. Am J Pathol 127:519–529
Farhood AI, Abrams J (1991) Immunohistochemistry of endometrial stromal sarcoma. Hum Pathol 22:224–230
Haas JE, Palmer NF, Weinberg AG, Beckwith JB (1981) Ultrastructure of malignant rhabdoid tumor of the kidney. Hum Pathol 12:646–657
Harris M, Eyden BP, Joglekar VM (1987) Rhabdoid tumour of the bladder: a histological, ultrastructural and immunohistochemical study. Histopathology 11:1083–1092
Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Kent AL, Mahoney DH, Gresik MV, Steuber CP, Fernbach DJ (1987) Malignant rhabdoid tumor of the extremity. Cancer 60:1056–1059
Kodet R, Newton WA, Sachs N, Hamoudi AB, Raney RB, Asmar L, Gehan EA (1991) Rhabdoid tumors of soft tissues: a clinico-pathologic study of 26 cases enrolled on the Intergroup Rhabdomyosarcoma Study. Hum Pathol 22:674–684
Lemos LB, Hamoudi AB (1978) Malignant thymic tumor in an infant (malignant histiocytoma). Arch Pathol Lab Med 102:84–89
Matias C, Nunes JFM, Vicente LF, Almeida MO (1991) Primary malignant rhabdoid tumour of the vulva. Histopathology 18:576–578
McNutt MA, Bolen JW, Gown AM, Hammar SP, Vogel AM (1985) Coexpression of intermediate filaments in human epithelial neoplasms. Ultrastruct Pathol 9:31–43
Perrone T, Swanson PE, Twiggs L, Ulbright TM, Dehner LP (1989) Malignant rhabdoid tumor of the vulva: is distinction from epithelioid sarcoma possible? Am J Surg Pathol 13:848–858
Russo P, Taylor S (1986) Two extrarenal malignant rhabdoid tumors in older children. Pediatr Pathol 5:110–114
Schmidt D, Leuschner I, Harms D, Sprenger E, Schafer HJ (1989) Malignant rhabdoid tumor. A morphological and flow cytometric study. Pathol Res Pract 184:202–210
Sotelo-Avila C, Gonzales-Crussi F, DeMello D, Vogler C, Gooch WM, Gale G, Pena R (1986) Renal and extrarenal rhabdoid tumors in children: a clinicopathologic study of 14 patients. Semin Diagn Pathol 3:151–163
Tsokos M, Kouraklis G, Chandra RS, Bhagavan BS, Triche TJ (1989) Malignant rhabdoid tumor of the kidney and soft tissues. Arch Pathol Lab Med 113:115–120
Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1985) Malignant soft tissue neoplasms with the histologic features of renal rhabdoid tumors: an ultrastructural and immunohistochemical study. Hum Pathol 16:1235–1242
Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1987) The existence of rhabdoid cells in specified soft tissue sarcomas. Virchows Arch [A] 411:509–514
Viale G, Dell'Orto P, Braidotti P, Coggi G (1985) Ultrastructural localization of intracellular immunoglobulins in Epon-embedded human lymph nodes. An immunoelectron microscopic investigation using the immunogold staining (IGS) and the avidin-biotin-peroxidase complex (ABC) methods. J Histochem Cytochem 33:400–406
Weeks DA, Beckwith JB, Mierau GW, Luckey DW (1989a) Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor Study Pathology Center. Am J Surg Pathol 13:439–458
Weeks DA, Beckwith JB, Mierau GW (1989b) Rhabdoid tumor. An entity or a phenotype? Arch Pathol Lab Med 113:113–114
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Cattani, M.G., Viale, G., Santini, D. et al. Malignant rhabdoid tumour of the uterus: an immunohistochemical and ultrastructural study. Vichows Archiv A Pathol Anat 420, 459–462 (1992). https://doi.org/10.1007/BF01600519
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DOI: https://doi.org/10.1007/BF01600519