Summary
A new semidominant mutation in the house mouse, velvet coat (Ve), is described. Ve homozygotes, recognizable on day 5 of gestation by their deficiency of ectodermal cells, never produce mesoderm and are resorbed by days 9–10. Primary Ve action may occur during the formation of the blastocyst or during determination and differentiation of the inner cell mass, or both. Accordingly, Ve/Ve embryos may provide a useful model for investigating primary gene action during blastocyst formation and subsequent differentiation.
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Work supported by Research Grant CA 02662 from the National Cancer Institute. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care
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Granholm, N.H., Stevens, L.C. & Theiler, K. Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse. Anat Embryol 157, 237–242 (1979). https://doi.org/10.1007/BF00305164
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DOI: https://doi.org/10.1007/BF00305164