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Cytotoxic activity of monocytes againstToxoplasma gondii in acute, chronic and reactivated murine toxoplasmosis

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Abstract

The phagocytic activity and cytotoxicity of peripheral blood monocytes (against toxoplasma tachyzoites) was studied in acute, chronic and reactivated toxoplasma infected Swiss albino mice. During acute infection, a low phygocytic activity was observed on the 4th day post infection (dpi) (P<0.01) and a low monocyte cytotoxicity was noticed after the 2nd dpi (P<0.01) which further decreased till the 8th dpi. In contrast, both the parameters were significantly increased during chronic infection. Increase in monocytic cytotoxicity was manifested on the 3rd dpi (P<0.001) whereas phagocytosis showed an increase on the 12th dpi (P<0.05). The reactivated group showed no change in both the parameters when compared with the control immunosuppressed group (P>0.05).

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Authors and Affiliations

  1. Department of Parasitology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India

    M. Goyal & R. C. Mahajan

  2. Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India

    N. K. Ganguly

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  1. M. Goyal
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  2. N. K. Ganguly
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  3. R. C. Mahajan
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Goyal, M., Ganguly, N.K. & Mahajan, R.C. Cytotoxic activity of monocytes againstToxoplasma gondii in acute, chronic and reactivated murine toxoplasmosis. Med Microbiol Immunol 177, 339–348 (1988). https://doi.org/10.1007/BF02389906

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  • DOI: https://doi.org/10.1007/BF02389906

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