Abstract
The excretion of immunoreactive vasopressin (AVP) and neurophysins was determined in 24 h urine samples from 62 normal healthy children of various ages.
Five groups of children were selected: group I (n=7, aged 2 to 3 years), group II (n=13, aged 3 to 5 years), group III (n=16, aged 5 to 7 years), group IV (n=16, aged 7 to 9 years), group V (n=10, aged 9 to 11 years).
The method used for urine AVP determination consisted of an extraction using a procedure slightly modified from that of Miller and Moses [14], coupled to a radioimmunoassay.
The following urinary AVP excretions were obtained:
group I mean: 70.8 ng/m2/24 h range: 51–150 ng
group II mean: 54.1 ng/m2/24 h range: 17–113.6 ng
group III mean: 55.2 ng/m2/24 h range: 18–106 ng
group IV mean: 39.9 ng/m2/24 h range: 11.7–77.9 ng
group V mean: 39.4 ng/m2/24 h range: 25.8–64 ng
The excretion of AVP was significantly correlated to the daily urinary osmolality (P<0.001) whether expressed in ng/24 h (r=0.41) or in ng/m2/24 h (r=0.47).
Neurophysins excretion ranging between 7 and 1,278 ng/24 h is too variable to allow interpretation.
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Supported by INSERM (78.1.2125) and UER de Biologie Humaine (Lyon)
Submitted in partial fulfilment of a Sciences Thesis (3è cycle Université Claude Bernard Lyon) by A.M.-A.B.
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Allevard-Burguburu, A.M., Geelen, G., Semporé, B. et al. Urinary excretion of immunoreactive vasopressin in prepubertal children. Lack of correlation with urinary excretion of immunoreactive neurophysins. Eur J Pediatr 137, 291–294 (1981). https://doi.org/10.1007/BF00443260
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DOI: https://doi.org/10.1007/BF00443260