Abstract
From a series of 230 subjects with infantile spasms (I.S.) observed from 1955 to 1982, 191 cases with sufficient data on follow-up and evaluation were selected. The period of follow-up in 100 subjects ranged from 3 months to 3 years and was more than 3 years in the remaining 91 patients. Disappearance of spasms and normal psychomotor development was observed in 34 of the 61 idiopathic and post-infectious cases. In 130 subjects with secondary forms normal psychomotor development was observed in only two patients; disappearance of spasms was noted in 54 and normalisation of the EEG in 13 subjects. Satisfactory long term results can be obtained with a relatively low dose of corticotropin in a considerable number of patients having idiopathic and post-infectious forms of I.S. To obtain the best results treatment should be started as soon as possible.
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References
Aicardi J, Chevrie JJ (1978) Les spasmes infantiles. Arch Fr Pediatr 35:1015–1023
Bachman DS (1982) Use of valproic acid in treatment of infantile spasms. Arch Neurol 39:49–52
Berardi R, Baracchi MR, Borgogni P, Mattei R, Pizzetti M (1982) Illritmo circadiano del cortisolo durante trattamento prolungato con ACTH. Pediatr Med Chir 2:51–54
Bower BD, Jeavons PM (1961) The effect of corticotropin and prednisolone on infantile spasms with mental retardation. Arch Dis Child 36:23–33
Chevrie JJ, Aicardi J (1971) Le pronostic psychique des spasmes infantiles traités par l'ACTH ou les corticoides. Analyse statistique de 78 cas suivis plus d'un an. J Neurol Sci 12:351–357
Chevrie JJ, Aicardi J (1978) Convulsive disorders in the first year of life: neurological and mental outcome and mortality. Epilepsia 19:67–74
Cox PJN, Martin E (1959) Letter to the editor: Infantile spasms and hypsarrhythmia. Lancet 1:1099
Gibbs EL, Fleming MM, Gibbs FA (1954) Diagnosis and prognosis of hypsarrhythmia and infantile spasms. Pediatrics 13:66–73
Hrachovy RA, Frost JD, Kellaway P, Zion T (1979) A controlled study of prednisone therapy in infantile spasms. Epilepsia 20:403–407
Jeavons PM, Bower BD (1961) The natural history of infantile spasms. Arch Dis Child 36:17–22
Jeavons PM, Harper JR, Bower BD (1970) Long-term prognosis in infantile spasms: a follow-up report on 112 cases. Dev Med Child Neurol 12:413–421
Jeavons PM, Bower BD, Dimitrakoudi M (1973) Long-term prognosis of 150 cases of “West Syndrome”. Epilepsia 14:153–164
Lacy GR, Penry JK (1976) Infantile spasms. Raven Press, New York, p 169
Lerman P, Kivity S (1982) The efficacy of corticotropin in primary infantile spasms. J Pediatr 8:294–296
Livingston S, Eisner V, Pauli C (1958) Minor motor epilepsy; diagnosis, treatment and prognosis. Pediatrics 21:916–928
Low NL (1958) Infantile spasms with mental retardation. Treatment with cortisone and adrenocorticotropin. Pediatrics 22:1165–1169
Matsumoto A, Watanabe K, Negoro T, Sugiura M, Iwase K, Hara K, Miyazaki S (1981) Long term prognosis after infantile spasms: a statistical study of prognostic factors in 200 cases. Dev Med Child Neurol 23:51–65
Matsumoto A, Watanabe K, Negoro T, Sugiura M, Iwase K, Hara K, Miyazaki S (1981) Infantile spasms: etiological factors, clinical aspects and long term prognosis in 200 cases. Eur J Pediatr 135:239–244
Pavone L, Incorporata G, La Rosa M, Livolti S, Mollica F (1981) Treatment of infantile spasms with sodium dipropyl-acetic acid. Dev Med Child Neurol 23:454–461
Pollack MA, Zion TB, Kellaway P (1979) Long-term prognosis of patients with infantile spasms following ACTH therapy. Epilepsia 20:255–260
Riikonen R (1982) A long-term follow-up study of 214 children with the syndrome of infantile spasms. Neuropediatrics 13:14–23
Saraux H, Hudela J, Levy GP (1973) Un nouveau syndrome: La dysplasie ectodermique oculocutanée. Ann Oculist 2:121–126
Singer WD, Rabe EF, Haller JS (1980) The effect of ACTH therapy upon infantile spasms. Pediatrics 96:485–489
Sorel L, Dusaucy-Bauloye A (1958) A propos de 21 cas de hypsarrhythmia de Gibbs: son traitment spectaculaire par l'ACTH. Acta Neurol Psychiat Belgica 58:130–141
West WJ (1841) On a peculiar form of infantile convulsions. Lancet 1:724–725
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Fois, A., Malandrini, F., Balestri, P. et al. Infantile spasms-long term results of ACTH treatment. Eur J Pediatr 142, 51–55 (1984). https://doi.org/10.1007/BF00442591
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DOI: https://doi.org/10.1007/BF00442591