Abstract
New high dose pancreatic enzyme preparations could be potentially helpful to cystic fibrosis (CF) patients. The purpose of this study was to compare the efficacy of the new high dose pancreatic enzyme preparation, Nutrizym 22 with the standard preparation Nutrizym GR. Twenty-five CF children (aged 7–16 years) entered the study and 22 completed it; 3 did not, due to non-compliance. All were taking Nutrizym GR for at least 2 weeks before entering the study. A randomised double blind, crossover method using standard Nutrizym GR or double strength Nutrizym 22 capsules was carried out over two consecutive 14-day periods. Crossover analyses of variance showed no statistically significant differences in actual weight gain, appetite, abdominal pain, stool consistency or faecal fat during the prestudy and study periods. It is concluded that half the capsule numbers of the high strength preparation are just as effective as the standard capsule dosage.
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Abbreviations
- CF:
-
cystic fibrosis
References
Anderson CM, French JM, Sammons HG, Frazer AC, Gerrard JW, Smellie JM (1952) Coeliac disease: gastro-intestinal studies and the effect of dietary wheat flour. Lancet I:836–842
Goodchild M (1986) Practical management of nutrition and gastrointestinal tract in cystic fibrosis. J R Soc Med 79 [Suppl 12]:32–35
Heijerman HGM, Lamers CBHW, Dijkman JH, Bakker W (1990) Ranitidine compared with the demithylprostaglandin E2 analogue enprostil and adjunct to pancreatic enzyme replacement in adult cystic fibrosis. Scand J Gastroenterol [Suppl] 178:26–31
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E Merck Pharmaceuticals
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Shah, A., Dinwiddie, R., Madge, S. et al. High dose Nutrizym 22 in cystic fibrosis. Eur J Pediatr 152, 763–764 (1993). https://doi.org/10.1007/BF01953997
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DOI: https://doi.org/10.1007/BF01953997