Skip to main content
SpringerLink
Log in

Sarcomatous degeneration in Paget's bone disease

  • Original Papers
  • Clinical Oncology or Epidemiology
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Summary

The authors report 12 cases (8 men and 4 women) of sarcomatous degeneration in Paget's bone disease, with an average age of 72.3 years. Sarcomatous degeneration occurred often in polyostotic Paget's disease, and osteitis deformans was seen in 4 cases. Femur and pelvis were the most affected bones. Pain was a constant feature, whereas tumefaction and fracture were less common. Osteolytic lesions were more frequent than condensed or mixed lesions and radiological signs of malignancy were usually found. Seven cases were histologically clasiified as osteogenic sarcoma and 3 cases as fibrosarcoma. Electron microscopy was performed on 2 osteogenic sarcomas and in 1 case revealed microcylindrical inclusion in Pagetic osteoclasts and in multinucleated giant tumor cells, but none in mononucleated tumor cells. The average survival time for the patients in this study was only 4.5 months.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barry HC (1961) Sarcoma in Paget's disease of bone in Australia. J Bone Joint Surg 43 A: 1122–1134

    Google Scholar 

  2. Boutouras GD, Goodsitt E (1963) Sarcoma arising in Paget's disease. Report of two cases and review of the literature. J Intern Coll Surg 40:380–392

    Google Scholar 

  3. Choquette D, Haraou B, Altman RD, Pelletier JP (1983) Simultaneous multifocal sarcomatous degeneration in Paget's disease of bone. A hypothesis. Clin Orthop 179:308–311

    Google Scholar 

  4. Fergusson RJ, Yunis PhD, Yunis EJ (1978) The ultrastructure of human osteosarcoma: a study of nine cases. Clin Orthop 131:234–246

    Google Scholar 

  5. Friedlander GE, Mitchell MS (1976) A virally induced osteosarcoma in rats. A model for immunological studies of human osteosarcoma. J Bone Joint Surg 58 A:295–302

    Google Scholar 

  6. Fujinaga S, Poel WE, Dmochowski L (1970) Light and electron microscope studies of osteosarcomas induced in rats and hamsters by Harvey and Moloney sarcoma viruses. Cancer 30:1698–1708

    Google Scholar 

  7. Gherardi G, Lo Cascio V, Bonnuci E (1980) Fine structure of nucleic and cytoplasm of osteoclasts in Paget's disease of bone. Histopathology 4:63–74

    Google Scholar 

  8. Greditzer HG, Mc Leod RA, Unni KK, Peabout JB (1983) Bone sarcomas in Paget's disease. Radiology 146:327–333

    Google Scholar 

  9. Haibach H, Farrell C, Dittrich FJ (1985) Neoplasms arising in Paget's disease of bone: a study of 82 cases. Am J Clin Pathol 83:594–600

    Google Scholar 

  10. Hamdy RC (1981) Paget's disease of bone, Assessment and management. Praeger, Eastbourne, New York

    Google Scholar 

  11. Hauw JJ, Henin D, Chomette G, Escourolle R (1973) Sarcomes osseux développés sur localisations rachidiennes de maladie de Paget. Arch Anat Cytol Pathol 21:241–249

    Google Scholar 

  12. Hyang TL, Cohen NJ, Sahgal S, Tseng CH (1979) Osteosarcoma complicating Paget's disease of the spine with neurologic complications. Clin Orthop 141:260–265

    Google Scholar 

  13. Huvos AG (1979) Bone tumors. Diagnosis, treatment and prognosis. W.B. Saunders, Philadelphia

    Google Scholar 

  14. Huvos AG, Butler A, Bretsky SS (1983) Osteogenic sarcoma associated with Paget's disease of bone. Cancer 52:1489–1495

    Google Scholar 

  15. Mc Kenna RJ, Schwinn ChP, Soong KY, Higinbotham NL (1964) Osteogenic sarcoma arising in Paget's disease. Cancer 17:42–46

    Google Scholar 

  16. Marquant KH (1983) Intranuclear vermicellar bodies in human osteosarcoma and ossifying fibroma cells. J Cancer Res Clin Oncol 106:74–76

    Google Scholar 

  17. Mills BG, Singer FR (1976) Nuclear inclusions in Paget's disease of bone. Science 194:201–202

    Google Scholar 

  18. Mills BG, Singer FR, Weiner LP, Holst PA (1981) Immunohistological demonstration of respiratory syncytial virus antigens in Paget's disease of bone. Proc Natl Acad Sci USA 78:1209–1213

    Google Scholar 

  19. Mirra JM, Bauer FCH, Grant TT (1981) Giant cell tumor with viral-like intranuclear inclusions associated with Paget's disease. Clin Orthop 158:243–251

    Google Scholar 

  20. Morlock G, Sany J, Serre H (1975) Les sarcomes pagétiques. Rev Rhum Mal Osteoartic 42:669–678

    Google Scholar 

  21. Murray AB, Buscher H, Erfle V (1983) Intranuclear undulating membranous structures in cells of a human parosteal osteosarcoma. Ultrastruc Pathol 5:163–170

    Google Scholar 

  22. Paget J (1882) Additional cases of osteitis deformans. Med Clin Trans 65:225–236

    Google Scholar 

  23. Poreta C, Dhalin DC, Jame JM (1957) Sarcoma in Paget's disease of bone. J Bone Joint Surg 39 A:1314–1329

    Google Scholar 

  24. Price GH (1962) The incidence of osteogenic sarcoma in South-West England and its relationship to Paget's disease of bone. J Bone Joint Surg 44 B:366–376

    Google Scholar 

  25. Price GH, Goldie W (1969) Paget's sarcoma of bone; a study of eighty cases from the Bristol and the Leeds bone tumor registries. J Bone Joint Surg 51 B:205–224

    Google Scholar 

  26. Rebel A, Malkani K, Basle MF (1974) Anomalies nucléaires des ostéoclastes de la maladie osseuse de Paget. Nouv Presse Méd 3:1299–1301

    Google Scholar 

  27. Rebel A, Basle MF, Pouplard A, Malkani K, Filmon R, Le Patezour A (1980) Bone tissue in Paget's disease of bone. Ultrastructure and immunocytology. Arthritis Rheum 23:1104–1114

    Google Scholar 

  28. Rebel A, Basle MF, Pouplard A, Malkani K, Filmon R, Le Patezour A (1981) Towards a viral etiology for Paget's disease of bone. Metab Bone Dis Relat Res 4 and 5:235–238

    Google Scholar 

  29. Reddick RL, Michelicht HJ, Levine AM, Triche TJ (1980) Osteogenic sarcoma. A study of the ultrastructure. Cancer 45:64–71

    Google Scholar 

  30. Rubens-Duval A (1978) Aspects histologiques de la dégénérescence sarcomateuse de l'os pagétique. Rev Rhum Mal Osteoartic 42:663–668

    Google Scholar 

  31. Schajowicz F, Araujo ES, Berenstein M (1983) Sarcoma complicating Paget's disease of bone. A clinicopathological study of 62 cases. J Bone Joint Surg 65:299–307

    Google Scholar 

  32. Singer FR, Mills BG (1983) Evidence for a viral etiology of Paget's disease of bone. Clin Orthop 178:245–251

    Google Scholar 

  33. Smith J, Botet JF, Yeh SDJ (1984) Bone sarcomas in Paget's disease: a study of 85 patients. Radiology 152:583–590

    Google Scholar 

  34. Vacher-Lavenu MC, Louvel A, Daudet-Monsac M, Le Charpentier Y, Abelanet R (1981) Inclusions tubulo-filamenteuses intranucléaires dans les cellules multinucléées des tumeurs à cellules géantes des os. Etude ultrastructurale d'une série de 31 tumeurs. CR Acad Sc Paris Série III 293:639–644

    Google Scholar 

  35. Viola MV, Eilon G, Lazarus M (1982) Virus-like inclusions in osteosarcoma cells arising in Paget's disease. Lancet I:848

    Google Scholar 

  36. Welsh RA, Meyer AJ (1970) Nuclear fragmentation and associated fibrils in giant cell tumor of bone. Lab Invest 22:63–72

    Google Scholar 

  37. Wick MR, Siegal GP, Krishnan KV, Mc Leod RA, Greditzer HG (1981) Sarcomas of bone complicating osteitis deformans. Fifty years' experience. Ann J Surg Pathol 5:47–59

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Rheumatology, CHU, 1 Av. de l'Hôtel Dieu, F-49040, Angers Cedex, France

    P. Seret, J. C. Renier & M. Audran

  2. Laboratory of Histology-Embryology, UER Médecine, Rue Haute de Reculée, 49045, Angers Cedex, France

    M. F. Basle & A. Rebel

  3. Laboratory of Pathology, CHU, 1 Av. de l'Hôtel Dieu, F-49040, Angers Cedex, France

    J. P. Saint-Andre

  4. Laboratory of Pathology, Centre Anti-Cancéreux Paul Papin, 2, Rue Moll, F-49036, Angers Cedex, France

    G. Bertrans

Authors
  1. P. Seret
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. F. Basle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Rebel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. C. Renier
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. P. Saint-Andre
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Bertrans
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Audran
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seret, P., Basle, M.F., Rebel, A. et al. Sarcomatous degeneration in Paget's bone disease. J Cancer Res Clin Oncol 113, 392–399 (1987). https://doi.org/10.1007/BF00397726

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00397726

Key words

Search

Navigation