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Autoradiographische Studien über das Wachstum von Ehrlich-Ascites-Tumor-Kulturen unter dem Einfluß sensibilisierter Lymphocyten

Autoradiographic studies on the influence of sensitized lymphocytes on the growth of Ehrlich-ascites-tumor in cell culture

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Summary

Lymphocytes of mice sensitized against Ehrlich-Ascites-Tumor (EAT) inhibit the growth of EAT-cell cultures. This effect was demonstrated by the lower mitosis rate of the tumor cells and by the decrease of DNA metabolism in autoradiographic studies with H3-thymidin. After intraperitoneal transplantation of the tumor cells cultured with sensitized lymphocytes the ascites developed in the same manner as in animals injected with EAT cell cultures without added lymphocytes.

Zusammenfassung

Mit autoradiographischer Technik konnte nachgewiesen werden, daß Lymphocyten sensibilisierter Tiere das Wachstum, von EAT-Zellen in der Zellkultur beeinflussen. Nach intraperitonealer Überpflanzung des mit Lymphocyten kultivierten Tumors kommt es zu einer Ascitesbidung, die sich ncht von dem der Ascites-Kulturen ohne Zusatz von Lymphocyten unterscheidet.

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Authors and Affiliations

  1. Abteilung für klinische Immunologie des Universitäts-Krankenhauses Erlangen-Nürnberg, Erlangen-Nürnberg, Deutschland

    F. Scheiffarth, H. Warnatz & H. Starrach

Authors
  1. F. Scheiffarth
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  2. H. Warnatz
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  3. H. Starrach
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Diese Arbeit wurde mit Unterstützung der Deutschen Forschungsgemeinschaft ausgeführt.

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Scheiffarth, F., Warnatz, H. & Starrach, H. Autoradiographische Studien über das Wachstum von Ehrlich-Ascites-Tumor-Kulturen unter dem Einfluß sensibilisierter Lymphocyten. Z Krebs-forsch 71, 283–288 (1968). https://doi.org/10.1007/BF00524755

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  • DOI: https://doi.org/10.1007/BF00524755

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