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Die Einwirkung des Krebses auf den Zellumsatz verschiedener Organe der Maus

The effect of cancer on cell turnover in mice organs

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Summary

The turnover of DNA was studied by means of thymidiny14C in different organs of mice inoculated with solid growing ELD tumor. At a tumor size of 13% of body weight, total body weight is unchanged indicating relative kachexiay The mesenteric fat decreased. The liver and spleen increased in weight, a change that was accompanied by increased DNA synthesis. The DNA-turnover of all other organs remained unchanged. In the kidneys and muscles smaller cell populations were stimulated by the tumor inoculation to a transitory increase of DNA-synthesis. An early decrease of label in the spleen and a concomitant increase in the liver, kidney and muscle may indicate cell migration.

Zusammenfassung

Es wurde der DNS-Umsatz in den Organen von mit solid-wachsendem ELD-Krebs inokulierten Mäusen mittels 14C-Thymidin studiert. Bei einer Tumorgröße von 13% des Körpergewichtes ist das Gesamtkörpergewicht unverändert somit eine relative Kachexie anzeigend. Das Darmfett nahm ab. Leber und Milz zeigten Gewichtszunahme und deutliche Zeichen gesteigerter DNS-Synthese. Die übrigen Organe zeigten keine signifikanten Veränderungen im Zellumsatz. In Nieren und Muskeln ließ sich eine kurzfristige Stimulation der DNS-Synthese kleinerer Zellpopulationen als unmittelbare Folge der Krebsinoculation wahrscheinlich machen. Frühzeitiger Aktivitätsabfall in der Milz im Verein mit gleichzeitigem Anstieg in Leber, Nieren und Muskeln kann auf Zellwanderung hindeuten.

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Authors and Affiliations

  1. Hevesylaboratorium am Institut für theoretische Alkoholforschung Karolinska Institute, Stockholm, Schweden

    D. Lockner, U. Ericson & Å. Pettersson

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  1. D. Lockner
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  2. U. Ericson
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  3. Å. Pettersson
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Additional information

Dem Andenken unseres verstorbenen Chefs und Initiators dieser Arbeit Prof. Georg von Hevesy gewidmet.

Der „Rikaföreningen mot Cancer“ und der „Knut och Alice Wallenbergs Stifteise“ sei hiermit für die finanzielle Unterstützung dieser Arbeit herzlich gedankt.

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Lockner, D., Ericson, U. & Pettersson, Å. Die Einwirkung des Krebses auf den Zellumsatz verschiedener Organe der Maus. Z. Krebsforsch. 77, 1–8 (1972). https://doi.org/10.1007/BF00284348

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  • DOI: https://doi.org/10.1007/BF00284348

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