Summary
Rats (weight 150–200 g) bearing Walker-carcinoma showed tumour size dependent hypoglycemia, diminished mobilization of glycogen following glucagon stimulation and elevated values of the enzyme activity of glucose-6-(P)-ase. A further hormonal stimulation of this enzyme activity towards the values observed in normal rats after betamethasone stimulation was not possible. The values of the enzyme fructose-1,6-di-(P)-ase in liver of tumour bearing rats equalled those found in normal controls and did not show any rise after application of betamethasone. The serum levels of free fatty acids did not show any difference between normal controls and tumour bearing rats, and displayed an equal rise after intensive stimulation of peripheral lipolysis.
Zusammenfassung
150–200 g schwere Tumorratten (Walker-Carcinom 256) zeigen eine tumorgrößenabhängige Spontanhypoglykämie, eine verminderte Glykogenmobilisation nach Glucagon (200γ/Tier) sowie erhöhte Spontanwerte der Glucose-6-(P)-ase. Eine weitere Steigerung der Aktivität der Glucose-6-(P)-ase durch Glucagon oder Bethamethason (7 mg/3 Tage) auf den bei Normaltieren beobachteten Maximalwert war nicht möglich. Die Aktivitätswerte der Leberfructose-1,6-di-(P)-ase bei Tumortieren glichen denen spontaner Normaltierwerte und waren im Gegensatz zu Normaltieren nicht durch Betamethason stimulierbar. Die freien Fettsäuren des Serums von Normalund Tumortieren zeigten gleiche Spontanwerte und gleichen Anstieg nach Stimulation der peripheren Lipolyse.
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Schulze, B., Buchelt, L., Kurtze, G. et al. Biochemische Untersuchungen zum Problem der Tumorkachexie. Z. Krebsforsch. 85, 21–28 (1976). https://doi.org/10.1007/BF00308125
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DOI: https://doi.org/10.1007/BF00308125