Summary
Small bowel absorption of glucose and leucin was investigated under the influence of somatostatin (SST) using an isolated Thiry Vella loop in the unrestrained dog. SST infusion significantly reduced glucose and leucin absorption, inhibiting glucose absorption more than that of leucin.
Zusammenfassung
In einer Resorptionsstudie an der isolierten Thiry Vella-Schlinge am wachen Hund wurde der Einfluß von Somatostatin (SST) auf die Dünndarmresorption von Glukose und Leucin untersucht. Unter SST wurde eine signifikante, aber nicht totale Hemmung der Glukoseresorption und eine prozentuell geringere signifikante Verminderung der Leucinresorption gefunden.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Bloom SR, Russel RCC, Barros d'Sa AAJ, Baron JH, Besser GM, Hall R, Coy DH, Kastin AJ, Schally A (1975) Inhibition of gastrin and gastric acid by growth hormone release inhibitory hormone. Gut 16:396–403
Boden G (1975) Somatostatin suppresses secretin and pancreatic exocrine secretion. Science 190:163–170
Brazeau R, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179:77–80
Dudrick SJ, Steiger E, Wilmore DW, Vars HM (1970) Continous long-term intravenous infusion in unrestrained animals. Lab Anim Care 20:521–525
Elde R, Höfkelt T, Johannson O, Schultzberg M, Efendic S, Luft R (1978) Cellular localisation of somatostatin. Metabolism [Suppl 1] 27:1151–1159
Evensen D, Hanssen KF, Berstad A (1978) Inhibition of intestinal calcium absorption in man. Metab [Suppl 1] 27:1345–1348
Gardner JD, Brown MS, Laster L (1970) The columnar epithelial cell of the small intestine: digestion and transport (1st of three parts). N Engl J Med 283:1196–1205
Gardner JD, Brown MS, Laster L (1970) The columnar epithelial cell of the small intestine: digestion and transport (2nd of three parts). N Engl J Med 283:1264–1271
Goldberg DJ, Waselsky M, Sherwin RS (1979) Effect of somatostatin on the plasma amino acid response to ingested protein in man. Metabolism 28:866–873
Hengl G, Prager J, Pointner H (1979) The influence of SST on the absorption of triglycerides in partially gastrectomized subjects. Acta Hepato-Gastroenterol 26:391–395
Hengl G, Prager J, Mörz R, Pointner H, Deutsch E (1980) Weitere Untersuchungen zur Frage der Somatostatin-Wirkung auf die Triglyceridresorption. Wien Med Wochenschr 2:49–52
Hummelt H, Jennewein HM, Treichel R, Waldeck C (1977) Somatostatin mode of action on gastric acid secretion in dogs. Digestion 15:151–155
Hyden S (1956) A turbidometric method for the determination of higher polyethylene glycols in biological materials. K Lantbr Högsk Annlr 22:139–142
Johnston ChG (1980) A method for making quantitative intestinal studies. Proc Exp Biol Med 30:26–31
Krebs HA, Henseleit K (1932) Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe Seylers Z Physiol Chem 210:33–39
Krejs GJ, Browne R, Raskin P (1978) Inhibition of jejunal sugar and amino acid absorption in man. Clin Res 26:I, 420
Krejs GJ, Browne R, Raskin P (1980) Effect of intravenous somatostatin on jejunal absorption of glucose, amino acids, water, and electrolytes. Gastroenterol 78:26–30
Laggner A, Pointner H, Deutsch E (1980) The influence of somatostatin on intestinal absorption. Studies with fluorescein-sodium. Regul Pept 1:61–67
Larsson LI, Goltermann N, Magistris I, Rehfeld JF, Schwartz TW (1979) Somatostatin cell processes as pathways for paracrine secretion. Science 205:1393–1397
Pointner H, Hengl G, Bayer PM, Flegel U (1977) Hemmung des postprandialen Triglyceridanstiegs im Serum durch Somatostatin beim Menschen. Wien Klin Wochenschr 89:224–228
Pott G, Wagner H, Zierden E, Hilke KH, Jansen H, Hengst K, Gerlach U (1979) Influence of somatostatin on carbohydrate absorption in human small intestine. Klin Wochenschr 57:131–133
Raptis S, Schlegel D, Lehmann HC, Zoupas Ch (1978) Effects of somatostatin on exocrine pancreas and the release of duodenal hormones. Metabolism [Suppl 1] 27:1321–1325
Ruppin H, Soergel KH (1980) Diffusionspotentiale und osmotische Einflüsse auf die Potentialdifferenz des menschlichen Dünndarms. Int Symp Diarrhoe-Intestinale Transportstörungen, pathologische und klinische Aspekte, Erlangen
Samnegard H, Thulin L, Andeen M (1979) Circulatory effects of somatostatin in anesthetized dogs. Acta Chir Scand 145:209–212
Schusdziarra V, Zyznar E, Rouiller D, Boden G, Brown JC, Arimura A, Unger RH (1980) Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis. Science 207:530–532
Spackman DH, Stein WH, Moore S (1958) Automatic recording apparatus for use in the chromatography of amino acids. Anal Chem 30:1190–1195
Stadaas JO, Schrumpf D, Hansen KF (1978) Somatostatin inhibits gastric motility in response to distension. Scand J Gastroenterol 13:145–148
Varrò V, Blaho G, Csernay J, Szarvas F (1965) Effect of decreased local circulation on the absorptive capacity of a small intestine loop in the dog. Am J Dig Dis 10:170–177
Wahren J, Fehlig P (1976) Influence or somatostatin on carbohydrate disposal and absorption in diabetes mellitus. Lancet 1:1213–1216
Wagner G, Hengst K, Jansen H, Gerlach V (1978) Effects of somatostatin on absorption of mono- and disaccharides in small intestine in vivo and in vitro in man and rats. Metabolism [Suppl 1] 27:1329–1332
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mörz, R., Hengl, G., Prager, J. et al. Hemmung der Glukose und Leucin-Resorption durch Somatostatin beim Hund. Res. Exp. Med. 178, 241–246 (1981). https://doi.org/10.1007/BF01851013
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851013