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Immunoreactive atrial natriuretic peptide (ANP) in endoscopic biopsies of the human gastrointestinal tract

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Research in Experimental Medicine

Summary

The human gastrointestinal tract, important for body salt and water balance, was investigated by endoscopic biopsy for the presence of atrial natriuretic peptide (ANP). Using immunohistochemistry, ANP-immunoreactive cells were identified in the lamina epithelialis mucosae of stomach, duodenum, jejunum, colon, and rectum. The findings indicate that ANP plays a role in intestinal salt and water regulation in man. ANP measurements in tissue specimens reached by endoscopic biopsy may be of major interest for future investigations on (patho-)physiological and pharmacological aspects of ANP.

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Authors and Affiliations

  1. Klinikum Großhadern, Neurologische Universitätsklinik, München, FRG

    H. Ehrenreich

  2. Institut für Tieranatomie II, Universität München, München, FRG

    F. Sinowatz

  3. Institut für Pharmakologie, Toxikologie und Pharmazie der Universität München, München, FRG

    R. Schulz

  4. Medizinische Klinik I, Klinikum Großhadern, Universität München, München, FRG

    R. M. Arendt

  5. Medizinische Poliklinik, Universität München, Pettenkoferstr. 8a, D-8000, München 2, FRG

    F. -D. Goebel

Authors
  1. H. Ehrenreich
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  2. F. Sinowatz
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  3. R. Schulz
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  4. R. M. Arendt
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  5. F. -D. Goebel
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Ehrenreich, H., Sinowatz, F., Schulz, R. et al. Immunoreactive atrial natriuretic peptide (ANP) in endoscopic biopsies of the human gastrointestinal tract. Res. Exp. Med. 189, 421–425 (1989). https://doi.org/10.1007/BF01855009

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  • DOI: https://doi.org/10.1007/BF01855009

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