Summary
Rats were sensitized with one dose of 20, 30, or 100, or three doses of 30Trichinella spiralis larvae and then given a challenge infection with 100 third-stage larvae ofAngiostrongylus cantonensis during different periods of development ofT. spiralis. A significant reduction in the mean number of adultA. cantonensis was found in all the experimental groups. The mean number of lung worms found in the groups varied from 56 to 68, whereas a mean of 82 was found in the control. This reduction is probably caused by the non-specific inflammatory reaction and cell-mediated response induced byT. spiralis in the intestine and other organs of the host. A weaker and slower haemagglutinating antibody response againstA. cantonensis was observed in animals infected with both species of nematodes. This may be attributed to a suppressive action elicited byT. spiralis against unrelated antigens. Changes in differential and total white blood cell counts were followed in some infected animals. An increase in neutrophils 3–4 weeks after infection with either or both species of parasites was observed. Eosinophilia occurred primarily in the lung phase of the metastrongyloid infection.
Similar content being viewed by others
References
Au, A.C.S., Ko, R.C.: Changes in worm burden, haematological and serological response in rats after single and multipleAngiostrongylus cantonensis infections. Z. Parasitenkd.58, 233–242 (1979)
Barriga, O.O.: Selective immunodepression in mice byTrichinella spiralis extracts and infections. Cell. Immunol.17, 306–309 (1975)
Basten, A., Boyer, M.H., Beeson, P.B.: Mechanism of eosinophilia I. Factors affecting the eosinophil response of rats toTrichinella spiralis. J. Exp. Med.131, 1271–1287 (1970)
Bruce, R.G., Wakelin, D.: Immunological interactions betweenTrichinella spiralis andTrichuris muris in the intestine of the mouse. Parasitology74, 163–173 (1977)
Cypess, R.H., Lubiniecki, A.S., Hammon, W.M.: Immunosuppression and increased susceptibility to Japanese B encephalitis virus inTrichinella spiralis infected mice. Proc. Soc. Exp. Biol. Med.143, 469–473 (1973)
Cypess, R.H., Lubiniecki, A.S., Swidwa, D.M.: Decreased susceptibility toListeria monocytogenes in mice after infection withTrichinella spiralis. Infect. Immun.9, 477–479 (1974a)
Cypess, R.H., Molinari, J.A., Ebersole, J.L., Lubiniecki, A.S.: Immunological sequelae ofTrichinella spiralis infection in mice. II. Potentiation of cell-mediated response to BCG after infection withTrichinella spiralis. Infect. Immun.10, 107–115 (1974b)
Dineen, J.K., Gregg, P., Windon, R.G., Donald, A.D., Kelly, J.D.: The role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes. Int. J. Parasitol.7, 211–215 (1977)
Faubert, G.M.: Depression of the plaque-forming cells to sheep red blood cells by the new-born larvae ofTrichinella spiralis. Immunology30, 485–489 (1976)
Faubert, G.: Le phénomène d'immunodépression temporaire observé dans la Trichinose. Est-il en relation avec l'acceptation de ca parasite par l'hôte? Ann. Immunol. (Paris)128c, 281–282 (1977)
Jones, J.F., Crandall, C.C., Crandall, R.B.: T-dependent suppression of the primary antibody response to sheep erythrocyte in mice infected withTrichinella spiralis. Cell. Immunol.27, 102–110 (1976)
Kagan, I.G., Norman, L.: Serodiagnosis of parasitic diseases. In: Manual of clinical microbiology, J.E. Blair, E.H. Lennette, J.P. Truant, eds. p. 453–486. Bethesda, Md.: American Society of Microbiology. 1970
Kazacos, K.R.: Increased resistance in the rat toNippostrongylus brasilliensis following immunization againstTrichinella spiralis. Vet. Parasitol.1, 165–174 (1976)
Kocan, A.A.: Influence ofNippostrongylus brasiliensis on establishment ofAngiostrongylus cantonensis in laboratory rat. Proc. Helminthol. Soc. Wash.4, 237–241 (1974)
Larsh Jr., J.E., Race, G.J.: Allergic inflammation as a hypothesis for the expulsion of worms from tissues. A Review. Exp. Parasitol.37, 251–266 (1975)
Louch, C.D.: Increased resistance toTrichinella spiralis in the laboratory rat following infection withNippostrongylus muris. J. Parasitol.48, 24–26 (1962)
Lowry, O.H., Rosebrough, A.C., Farr, A.L., Randall, R.J.: Protein measurement with the folin phenol reagent. J. Biol. Chem.193, 265–275 (1951)
Lubiniecki, A.S., Cypess, R.H.: Quantitative study of the effect of previousTrichinella spiralis infection on sarcoma 180 ascitic tumor formation in mice. Tropenmed. Parasitol.26 329–333 (1975)
Yoshimura, K., Soulsby, E.J.L.:Angiostrongylus cantonensis: Lymphoid cell responsiveness and antibody production in rats. Am. J. Trop. Med. Hyg.25, 99–107 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Au, A.C.S., Ko, R.C. Cross-resistance betweenTrichinella spiralis andAngiostrongylus cantonensis in laboratory rats. Z. Parasitenkd. 59, 161–168 (1979). https://doi.org/10.1007/BF00927398
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00927398