Abstract
We compared two murine models of Trypanosoma rangeli infection. The same inoculum dose and age-matched hosts were used in both cases. One group was infected with trypomastigotes obtained from passages in mice and the other, with trypomastigotes obtained from cell culture after a passage in mice. We observed that trypomastigotes obtained from the in vitro cellular infection showed increased virulence in␣experimental animals, with a 70% rate of death being noted in experimental mice instead of the lack of mortality seen when in vivo-derived parasites were used. The greatest levels of parasitemia and tissual lesions in the presence of the parasite also occurred when in vitro-derived parasites were used.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 10 March 1997 / Accepted: 10 April 1997
Rights and permissions
About this article
Cite this article
Zuñiga, C., Palau, M., Penin, P. et al. Trypanosoma rangeli : increase in virulence with inocula of different origins in the experimental infection in mice. Parasitol Res 83, 797–800 (1997). https://doi.org/10.1007/s004360050342
Issue Date:
DOI: https://doi.org/10.1007/s004360050342