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bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein inNeurospora crassa

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Abstract

Blue light plays an important role in developmental control throughout nature. Thebli-4 gene ofNeurospora crassa, together withbli-3, al-1 andal-2, is rapidly inducible by blue light. Induction leads to a ninety-fold increase in transcription rate over the dark control level, and the gene therefore appears to be of prime importance in the blue-light induction pathway ofN. crassa. We describe the sequencing and analysis ofbli-4 and the 38 kDa protein it encodes. We show that the protein is very rapidly imported into the mitochondria and exhibits high homology with the family of short-chain alcohol dehydrogenases.

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Author notes

  1. J. J. P. Bruchez & A. Radford

    Present address: Department of Genetics, The University of Leeds, LS2 9JT, Leeds, UK

  2. J. Eberle

    Present address: Dermatology Department, University Medical Centre Benjamin-Franklin, Hindenburgdamm 30, D-12200, Berlin, Germany

  3. W. Kohler

    Present address: Cellpro Germany GmbH, Leopoldstr. 28a, D-80802, Munich, Germany

  4. V. Kruft & V. E. A. Russo

    Present address: Applied Biosystems GmbH, Brunnenweg 13, D-64331, Weiterstadt, Germany

Authors and Affiliations

  1. Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, D-14195, Berlin, Germany

    J. J. P. Bruchez, J. Eberle, W. Kohler, V. Kruft, A. Radford & V. E. A. Russo

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  1. J. J. P. Bruchez
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  2. J. Eberle
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  3. W. Kohler
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  6. V. E. A. Russo
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Communicated by C. A. M. J. J. van den Hondel

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Bruchez, J.J.P., Eberle, J., Kohler, W. et al. bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein inNeurospora crassa . Molec. Gen. Genet. 252, 223–229 (1996). https://doi.org/10.1007/BF02173767

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  • DOI: https://doi.org/10.1007/BF02173767

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