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Follow-up till age 3–4 of unselected children with sex chromosome abnormalities

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Summary

Follow-up examination of 15 unselected children with aneuploid sex chromosome abnormalities has been made till between the age of 21/2 and 5 years. The mental development of the 15 children was in all cases within the normal range, but there was a tendency to some differences compared with their siblings.

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References

  • Annell, A.-L., Gustavson, K.-H., Tenstam, J.: Symptomatology in schoolboys with positive sex chromatin (The Klinefelter syndrome). Acta psychiat. scand. 46, 71–80 (1970)

    Google Scholar 

  • Barlow, P.: The influence of inactive chromosomes on human development. Anomalous sex chromosome complements and the phenotype. Humangenetik 17, 105–136 (1973)

    Google Scholar 

  • Bochkov, N. P., Kuleshov, N. P., Chebotarev, A. N., Alekhin, V. I., Midian, S. A.: Population cytogenetic investigation of newborns in Moscow. Humangenetik 22, 139–152 (1974)

    Google Scholar 

  • Forssman, H., Wahlström, J., Wallin, L., Åkesson, H. O.: Males with double Y-chromosomes. Göteborg: Akademiförlaget 1975

    Google Scholar 

  • Friedrich, U., Nielsen, J.: Chromosome studies in 5,049 consecutive newborn children. Clin. Genet. 4, 333–343 (1973)

    Google Scholar 

  • Garvey, M., Mutton, D. E.: Sex chromosome aberrations and speech development. Arch. Dis. Childh. 48, 937–941 (1973)

    Google Scholar 

  • Gerald, P. S., Walzer, S.: Chromosome studies of normal newborn infants. In: Human population cytogenetics (eds. P. A. Jacobs, W. H. Price, P. Law), pp. 143–151. Pfizer Medical Monographs 5. Edinburgh: University Press 1970

    Google Scholar 

  • Hambert, G., Wetterberg, L.: Chromosomal aberrations and acute intermittent porphyria. Lancet 1964 II, 419

    Google Scholar 

  • Hamerton, J. L., Canning, N., Ray, M., Smith, S.: A cytogenetic survey of 14,069 newborn infants. Incidence of chromosome abnormalities. Clin. Genet. (in press, 1975)

  • Hamerton, J. L., Ray, M., Abbott, J., Williamson, C., Ducasse, G. C.: Chromosome studies in a neonatal population. Canad. med. Ass. J. 106, 776–779 (1972)

    Google Scholar 

  • Hook, E. B.: Behavioral implications of the human XYY genotype. Science 179, 139–150 (1973)

    Google Scholar 

  • Jacobs, P. A., Melville, M., Ratcliffe, S., Keay, A. J., Syme, J.: A cytogenetic survey of 11,680 newborn infants. Ann. hum. Genet. 37, 359–376 (1974)

    Google Scholar 

  • Keutel, J.: XYY-Status bei Kindern. Z. Kinderheilk. 106, 314–332 (1969)

    Google Scholar 

  • Kiss, P., Osztovics, M., Erényi, J., Örley, J.: Sex chromosome aberrations in childhood. Acta paediat. Acad. Sci. hung. 13, 1–17 (1972)

    Google Scholar 

  • Kivowitz, J.: The XYY syndrome in children: A review. Child Psychiat. hum. Develop. 2, 186–194 (1972)

    Google Scholar 

  • Kivowitz, J., Corcoran, J.: Theoretical and practical considerations of Klinefelter's syndrome in children. A report of three cases of 47,XXY. J. Amer. Acad. Child Psychiat. 10, 700–712 (1971)

    Google Scholar 

  • Laron, Z., Hochman, I. H.: Small testes in prepubertal boys with Klinefelter's syndrome. J. clin. Endocr. 32, 671–672 (1971)

    Google Scholar 

  • Lubs, H. A., Ruddle, F. H.: Chromosomal abnormalities in the human population: estimation of rates based on New Haven newborn study. Science 169, 495–497 (1970a)

    Google Scholar 

  • Lubs, H. A., Ruddle, F. H.: Applications of quantitative karyotype to chromosome variation in 4400 consecutive newborns. In: Human population cytogenetics (eds. P. A. Jacobs, W. H. Price, P. Law), pp. 119–142. Pfizer Medical Monographs 5. Edinburgh: University Press 1970b)

    Google Scholar 

  • Nielsen, J.: Klinefelter's syndrome and acute intermittent porphyria. Lancet 1966 I, 984

  • Nielsen, J.: Cytogenetic investigation of patients with schizophrenia. Symposium on Aspects of Schizophrenia, Yerevan and Tblisi, USSR, on October 8–12 (1973)

  • Nielsen, J.: Chromosome examination of newborn children. Purpose and ethical aspects. Humangenetik 26, 215–222 (1975)

    Google Scholar 

  • Nielsen, J., Bjarnason, S., Friedrich, U., Frøland, A., Hansen, V. H., Sørensen, A.: Klinefelter's syndrome in children. J. Child Psychol. 11, 109–119 (1970)

    Google Scholar 

  • Nielsen, J., Christensen, A.-L.: Thirty-five males with double Y chromosome. J. Psychol. Med. 4, 28–37 (1974)

    Google Scholar 

  • Nielsen, J., Christensen, K. R., Friedrich, U., Zeuthen, E., Østergaard, O.: Childhood of males with the XYY syndrome. J. Autism Childh. Schizophr. 3, 5–26 (1973)

    Google Scholar 

  • Nielsen, J., Sillesen, I.: Incidence of chromosome aberrations among 11,148 newborn children. Humangenetik 30, 1–12 (1975)

    Google Scholar 

  • Nielsen, J., Sørensen, A., Theilgaard, A., Frøland, A., Johnsen, S. G.: A psychiatric-psychological study of 50 severely hypogonadal male patients, including 34 with Klinefelter's syndrome. 47,XXY. Acta psychiat. scand., Suppl. 209 (1969)

  • Noël, B., Duport, J. P., Revil, D., Dussuyer, I., Quack, B.: The XYY syndrome: Reality or myth? Clin. Genet. 5, 387–394 (1974)

    Google Scholar 

  • Olanders, S.: Kvinnor med övertaliga X-kromosomer. En studie av 39 psykiatriska fall. St. Jörgens sjukhus, Hisings Backa, Göteborg (1974)

  • Schibler, D., Brook, C. G. D., Kind, H. P., Zachmann, M., Prader, A.: Growth and body proportions in 54 boys and men with Klinefelter's syndrome. Helv. paediat. Acta 29, 325–333 (1974)

    Google Scholar 

  • Sergovich, F., Valentine, G. H., Chen, A. T. L., Kinch, R. A. H., Smout, M. S.: Chromosome aberrations in 2159 consecutive newborn babies. New Engl. J. Med. 280, 851–855 (1969)

    Google Scholar 

  • Tennes, K., Puck, M., Bryandt, K., Frankenburg, W., Robinson, A.: A developmental study of girls with trisomy X. Amer. J. hum. Genet. 27, 71–80 (1975)

    Google Scholar 

  • Tolksdorf, M.: Klinefelter's syndrome and Turner's syndrome in childhood. Helv. paediat. Acta 29, suppl. 34, 137–151 (1974)

    Google Scholar 

  • Tsuang, M. T.: Sex chromatin anomaly in Chinese females: Psychiatric characteristics of XXX. Brit. J. Psychiat. 124, 299–305 (1974)

    Google Scholar 

  • Tulinius, H., Tryggvason, K., Hauksdottir, H.: 45,X/46,XY chromosome mosaic with features of the Russell-Silver syndrome: A case report with a review of the literature. Develop. med. Child. Neurol. 14, 161–172 (1972)

    Google Scholar 

  • Walzer, S., Breau, G., Gerald, P. S.: A chromosome survey of 2,400 normal newborn infants. J. Pediat. 74, 438–448 (1969)

    Google Scholar 

  • Walzer, S., Gerald, P. S.: Chromosome abnormalities in 11,154 newborn infants. Amer. J. hum. Genet. 24, 38a (1972)

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Nielsen, J., Sillesen, I. Follow-up till age 3–4 of unselected children with sex chromosome abnormalities. Hum Genet 33, 241–257 (1976). https://doi.org/10.1007/BF00286848

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