Summary
Instability of the centromeric regions of chromosomes 1, 9, and 16 in cultured lymphocytes of an 8-month-old girl with malabsorption and combined immunodeficiency is reported. Together with the two previous reports on this condition, the present report seems to confirm the specific association of combined immunodeficiency and centromeric instability of chromosomes 1, 9 and 16 with multibranching.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fryns JP, Van den Berghe H (1980) Balanced transmission of centric fission products in man. Hum Genet 54:127–128
Hecht F, Kaiser-McCaw B (1979) Editorial. The importance of being a fragile site. Am J Hum Genet 31:223–225
Hulten M (1978) Selective somatic pairing and fragility at 1q12 in a boy with common variable immunodeficiency. Clin Genet 14:294
Morad M, Jonasson J, Lindsten J (1973) Distribution of mitomycin C induced breaks on human chromosomes. Hereditas 74:273–282
Sutherland GR (1979) heritable fragile sites on human chromosomes. II. Distribution, phenotypic effects, and cytogenetics. Am J Hum Genet 31:136–148
Tiepolo L, Maraschio P, Gimelli G, Cuoco C, Gargani GF, Romano C (1979) Multibranched chromosomes 1, 9, and 16 in a patient with combined IgA and IgE deficiency. Hum Genet 51:127–137
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fryns, J.P., Azou, M., Jaeken, J. et al. Centromeric instability of chromosomes 1, 9, and 16 associated with combined immunodeficiency. Hum Genet 57, 108–110 (1981). https://doi.org/10.1007/BF00271181
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00271181