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Expression of the fragile site Xq27 in fibroblasts. I. Detection of Fra(X)(q27) in fibroblast clones from males with X-linked mental retardation

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Summary

Twelve fibroblast clones from two males with X-linked mental retardation expressed the fragile site Xq27 in 3%–38% of metaphases analyzed. The number of in vitro doublings during the cloning procedure had no evident influence on the induction of fragile X expression. The variability of fragile X expression seems to depend on cell properties acquired during culture rather than on properties originally inherent in the cells.

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Authors and Affiliations

  1. Abteilung Klinische Genetik, Universität Ulm, Prittwitzstrasse 6, D-7900, Ulm/Donau, Federal Republic of Germany

    P. Steinbach, G. Barbi, S. Baur & A. Wiedenmann

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  1. P. Steinbach
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  2. G. Barbi
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  3. S. Baur
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  4. A. Wiedenmann
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Steinbach, P., Barbi, G., Baur, S. et al. Expression of the fragile site Xq27 in fibroblasts. I. Detection of Fra(X)(q27) in fibroblast clones from males with X-linked mental retardation. Hum Genet 63, 404–405 (1983). https://doi.org/10.1007/BF00274770

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  • DOI: https://doi.org/10.1007/BF00274770

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