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Nongranulated cells in the mouse adenohypophysis

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Summary

Follicular cells in the mouse adenohypophysis were studied electron microscopically. These elements appear to be very similar to the marginal cells that delineate both sides of the hypophyseal cleft.

The mouse differs from most other species in that the follicular cells in the pars distalis and the marginal cells look completely inactive in young, intact animals. This makes the mouse exceptionally favorable for correlating morphological changes in the cells of both types with changes in the physiological state of the animal. Different treatments applied in the present investigation all induced morphological reactions in the follicular and/or marginal cells; these reactions were generally similar. Thus, morphological changes in the follicular or marginal cells should be considered as general phenomena accompanying many changes in the physiological state of the animal, rather than as a specific result of the treatment applied.

In three experiments, the follicular and marginal cells were involved in the digestion of waste material from other cells. It is suggested that the morphological changes in the other experiments should also be interpreted as signs of such an activity.

In the pars tuberalis of the young, intact mouse the follicular cells may show characteristics that in the pars distalis are found only under experimental conditions. Therefore, the follicular cells in this part of the hypophysis are probably in an active state.

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Authors and Affiliations

  1. Department of Electron Microscopy, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    K. P. Dingemans & Constance A. Feltkamp

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  1. K. P. Dingemans
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  2. Constance A. Feltkamp
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Dingemans, K.P., Feltkamp, C.A. Nongranulated cells in the mouse adenohypophysis. Z. Zellforsch. 124, 387–405 (1972). https://doi.org/10.1007/BF00355038

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  • DOI: https://doi.org/10.1007/BF00355038

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