Skip to main content
SpringerLink
Log in

Intranuclear inclusions in pericytes of the hypothalamus of the rat

  • Published:
Cell and Tissue Research Aims and scope Submit manuscript

Summary

This paper deals with the ultrastructure of two types of intranuclear inclusions, “nuclear bodies” and “membranous lamellar bodies”, present in hypothalamic pericytes of intact adult rats. The nuclear bodies exhibited “simple” and “granular” forms, whereas the membranous lamellar bodies were entirely made up of myelin-like membrane whorls.

The occurrence of these bodies in nuclei of pericytes has never been previously reported. The origin and functional meaning of such structures is discussed in the light of recent ultrastructural and biochemical studies on nuclear inclusions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Azevedo, C.: Intranuclear membranous inclusions in oocytes of a viviparous teleost (Xiphophorus helleri). J. Cell Sci. 22, 325–334 (1976)

    Google Scholar 

  • Blinzinger, K., Anzil, A.P.: Large granular nuclear bodies (Karyosphaeridia) in experimental Borna virus infection. J. comp. Path. 83, 589–596 (1973)

    Google Scholar 

  • Bouteille, M., Kalifat, S.R., Delarue, J.: Ultrastructural variations of nuclear bodies in human diseases. J. Ultrastruct. Res. 19, 474–486 (1967)

    Google Scholar 

  • Bouteille, M., Laval, M., Dupuy-Coin, A.M.: Localization of nuclear functions as revealed by ultrastructural autoradiography and cytochemistry. In: The cell nucleus, Vol. 1 (H. Busch, ed.). New York: Academic Press 1974

    Google Scholar 

  • Büttner, D.W., Horstmann, E.: Das Sphaeridion — eine verbreitete Differenzierung des Karyoplasma. Z. Zellforsch. 77, 589–605 (1967)

    Google Scholar 

  • Cancilla, P.A., Baker, R.N., Pollock, P.S., Frommes, S.P.: The reaction of pericytes of the central nervous system to exogenous protein. Lab. Invest. 26, 376–383 (1972)

    Google Scholar 

  • Chandler, R.L.: Demonstration of a porcine adenovirous by electron microscopy. Virology 25, 143–145 (1965)

    Google Scholar 

  • Dahl, E.: The fine structure of nuclear inclusions. J. Anat. (Lond.) 106, 255–262 (1970)

    Google Scholar 

  • Deurs, B. van: Observations on the blood-brain barrier in hypertensive rats with particular reference to phagocytic pericytes. J. Ultrastruct. Res. 55, 400–416 (1976)

    Google Scholar 

  • Dumont, A., Robert, A.: Ultrastructure of complex nuclear bodies produced experimentally in hamster peritoneal macrophages. J. Ultrastruct. Res. 36, 483–492 (1971)

    Google Scholar 

  • Dupuy-Coin, A.M., Bouteille, M.: Protein renewal in nuclear bodies, as studied by quantitative ultrastructural autoradiography. Exp. Cell Res. 90, 111–118 (1975)

    Google Scholar 

  • Dupuy-Coin, A.M., Kalifat, S.R., Bouteille, M.: Nuclear bodies as proteinaceous structures containing ribonucleoproteins. J. Ultrastruct. Res. 38, 174–187 (1972)

    Google Scholar 

  • El-Labban, N.G., Kramer, I.R.H.: Nuclear bodies in oral lichen planus. J. Ultrastruct. Res. 40, 470–479 (1972)

    Google Scholar 

  • Feldman, M.L., Peters, A.: Intranuclear rods and sheets in rat cochlear nucleus. J. Neurocytol. 1, 109–127 (1972)

    Google Scholar 

  • Folliot, R.: Les lamelles annelées intranucléaires des cellules du tissu germinal mâle avant la méiose chez Philaenus spumarius L. (Insecte Homoptère). Z. Zellforsch. 92, 115–129 (1968)

    Google Scholar 

  • Ghadially, F.N.: Ultrastructural pathology of the cell, pp. 80–82. London: Butterworths 1975

    Google Scholar 

  • Henry, K., Petts, V.: Nuclear bodies in human thymus. J. Ultrastruct. Res. 27, 330–343 (1969)

    Google Scholar 

  • Hinsch, G.W.: Possible role of intranuclear membranes in nuclear-cytoplasmic exchange in spider crab oocytes. J. Cell Bio. 47, 531–535 (1970)

    Google Scholar 

  • Humeau, C.: Formations membranaires dans le noyau et le cytoplasme périnucléaire due jeune ovocyte de Triturus helveticus Raz. C. R. Soc. Biol. (Paris) 162, 183–186 (1968)

    Google Scholar 

  • Kessel, R.G.: Annulate lamellae. J. Ultrastruct. Res., Suppl. 10, 1–82 (1968)

    Google Scholar 

  • Krishan, A., Uzman, B.G., Hedley-Whyte, E.T.: Nuclear bodies: a component of cell nuclei in hamster tissues and human tumors. J. Ultrastruct. Res. 19, 563–572 (1967)

    Google Scholar 

  • Lafarga, M., Palacios, G.: Ultrastructural study of pericytes in the rat supraoptic nucleus. J. Anat. (Lond.) 120, 433–438 (1975)

    Google Scholar 

  • Lafarga, M., Palacios, G.: Intranuclear rodlets in retrochiasmatic area neurons of the hypothalamus of the rat. Experientia (Basel) 33, 1368–1369 (1977)

    Google Scholar 

  • Le Goascogne, C., Baulieu, E.E.: Hormonally controlled “nuclear bodies” during the development of the prepuberal rat uterus. Biol. Cellulaire 30, 195–206 (1977)

    Google Scholar 

  • Levine, S., Sowinski, R., Hoenig, E.M.: Nuclear bodies produced in astrocytes by tilorone. Amer. J. Path. 78, 319–330 (1975)

    Google Scholar 

  • Monneron, A., Bernhard, W.: Fine structural organization of the interphase nucleus in some mammalian cells. J. Ultrastruct. Res. 27, 266–288 (1969)

    Google Scholar 

  • Nakayama, I., Nickerson, P.A.: Intranuclear inclusions in mammotrophs of the female Mongolian gerbil. Amer. J. Anat. 135, 93–104 (1972)

    Google Scholar 

  • Nickerson, P.A.: Effect of partial thyroidectomy, propylthiouracil or thyroxine on estrogen-induced intranuclear inclusions in mammotrophs of the Mongolian gerbil. Tissue & Cell 4, 763–772 (1975)

    Google Scholar 

  • Patrizi, G., Middelkamp, J.N.: In vivo and in vitro demonstration of nuclear bodies in vaccinia infected cells. J. Ultrastruct. Res. 28, 275–287 (1969)

    Google Scholar 

  • Popoff, N., Steward, S.: The fine structure of nuclear inclusions in the brain of experimental golden hamsters. J. Ultrastruct. Res. 23, 347–361 (1968)

    Google Scholar 

  • Rivas, C., Oliva, H.: Nuclear bodies in Hodgkin's disease. Path. europ. 9, 297–301 (1974)

    Google Scholar 

  • Scotto, J.M., Stralin, H.G.: Relationship between nuclear bodies and intranuclear invaginations in parenchymal liver cells of patients with viral hepatitis. J. Microscopie Biol. Cell. 25, 233–235 (1976)

    Google Scholar 

  • Seite, R., Escaig, J., Couineau, S.: Microfilaments et microtubules nucléaires et organisation ultrastructurale des bâtonnets intranucléaire des neurones sympathiques. J. Ultrastruct. Res. 37, 449–478 (1971)

    Google Scholar 

  • Simar, L.J.: Ultrastructure et constitution des corp nucléaires dans les plasmocytes. Z. Zellforsch. 99, 235–251 (1969)

    Google Scholar 

  • Smetana, K., Gyorkey, P., Busch, H.: Compact filamentous bodies of nuclei and nucleoli of human prostate gland. Exp. Cell Res. 64, 133–139 (1971)

    Google Scholar 

  • Tripier, M.F., Berard, M., Toga, M.: “Membranous nuclear bodies” as possible intermediate structures between nuclear bodies and invaginations of the nuclear envelope. J. Microscopie 21, 21–30 (1974)

    Google Scholar 

  • Weber, A., Whipp, S., Usenik, E., Frommes, S.: Structural changes in the nuclear body in the adrenal zona fasciculata of the calf following the administration of ACTH. J. Ultrastruct. Res. 11, 564–576 (1964)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histology, Faculty of Medicine, University of Santander, Spain

    Miguel Lafarga & José-Pablo Hervás

Authors
  1. Miguel Lafarga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. José-Pablo Hervás
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lafarga, M., Hervás, JP. Intranuclear inclusions in pericytes of the hypothalamus of the rat. Cell Tissue Res. 193, 315–322 (1978). https://doi.org/10.1007/BF00209043

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00209043

Key words

Search

Navigation