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The effect of a liquid elemental diet on cell proliferation in the colon of rats

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Summary

A liquid elemental diet (Vivonex) was given to rats for 6 days while control animals received a normal diet. At the end of the experiment each animal received one intraperitoneal injection of tritiated thvmidine at 8a.m. Animals from each group were killed hourly during the first 24h after the injection and the proliferative activity was studied by autoradiography of the mucosa of the colon using the labeled mitoses-wave method.

The epithelial cell proliferation was significantly decreased in the colon of the Vivonex-fed animals.

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References

  • Hagemann RF, Stragand JJ (1977) Fasting and refeeding: cell kinetic response of jejunum, ileum and colon. Cell Tissue Kinet 10:3–14

    Google Scholar 

  • Houck JC, Kanagalingam K, Kaufman SL, Sunshine G (1976) Evidence for a colon chalone. J Nat Canc Inst 56:899–902

    Google Scholar 

  • Janne P, Carpentier Y, Willems G (1977) Colonic mucosal atrophy induced by a liquid elemental diet in rats. Am J Dig Dis 22:808–812

    Google Scholar 

  • Mak KM, Chang WWL (1976) Pentagastrin stimulates epithelial cell proliferation in duodenal and colonic crypts in fasted rats. Gastroenterology 71:1117–1129

    Google Scholar 

  • Morin CL, Ling V, Bourassa D (1980) Small intestinal and colonic changes induced by a chemically defined rat. Dig Dis Sci 25:123–128

    Google Scholar 

  • Quastler H, Sherman FG (1959) Cell population kinetics in the intestinal epithelium of the mouse. Exp Cell Res 17:420–438

    Google Scholar 

  • Stragand JJ, Hagemann RF (1977) Effect of lumenal contents on colonic cell replacement. Am J Physiol 233:E208-E211

    Google Scholar 

  • Sunter JP, Wright NA, Appleton DR (1977) Cell population kinetics in the epithelium of the colon of the male rat. Virchows Arch (Cell Pathol) 26:275–287

    Google Scholar 

  • Willems G (1979) Cell population kinetics in the mucosa of the gastrointestinal tract. In: Duthie HL, Wormsley KG (ds) Scientific basis of gastroenterology. Churchill Livingstone, Edinburgh, pp 2–25

    Google Scholar 

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Authors and Affiliations

  1. Fakulteit Geneeskunde, Gastroenterology Research Unit, Vrije Universiteit Brussel, Brussels, Belgium

    G. Storme &  G. Willems M.D.

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  1. G. Storme
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  2. G. Willems M.D.
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Storme, G., Willems, G. The effect of a liquid elemental diet on cell proliferation in the colon of rats. Cell Tissue Res. 216, 221–225 (1981). https://doi.org/10.1007/BF00234557

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  • DOI: https://doi.org/10.1007/BF00234557

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