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A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy

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Abstract 

We have previously reported an 8-year-old girl with lipoprotein glomerulopathy. Assessment of serum apolipoprotein E (apo E) in this patient showed a discrepancy between phenotype and genotype, suggesting that she may have a variant of apo E. The present report concerns our analysis of DNA sequences of the apo E gene in the patient: nine base pairs were found to be deleted from exon 4. This mutation would appear to encode a new apo E variant lacking three amino acids. This variant may be associated with the pathogenesis of lipoprotein glomerulopathy.

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Authors and Affiliations

  1. Department of Pediatrics, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511 Japan Tel.: +81-27-220-8205, Fax: +81-27-220-8215, , , , , , JP

    T. Ogawa, K. Maruyama, H. Arai, T. Watanabe, Y. Kobayashi & A. Morikawa

  2. Research Department, R and D Center, BML, Inc., Kawagoe, Saitama, Japan, , , , , , JP

    H. Hattori, I. Kondoh & T. Egashira

Authors
  1. T. Ogawa
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  2. K. Maruyama
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  3. H. Hattori
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  4. H. Arai
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  5. I. Kondoh
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  6. T. Egashira
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  7. T. Watanabe
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  8. Y. Kobayashi
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  9. A. Morikawa
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Additional information

Received: 28 August 1998 / Revised: 2 February 1999 / Accepted: 5 February 1999

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Ogawa, T., Maruyama, K., Hattori, H. et al. A new variant of apolipoprotein E (apo E Maebashi) in lipoprotein glomerulopathy. Pediatr Nephrol 14, 149–151 (2000). https://doi.org/10.1007/s004670050032

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  • DOI: https://doi.org/10.1007/s004670050032

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