Abstract
Immunological parameters including serum IgG, IgA and IgM, lymphocyte phenotypes (CD3, CD4, CD8, HLA-DR+CD3-), natural killer cell activity and lymphocyte proliferation with phytohaemagglutinin were assessed in 10 children on continuous ambulatory peritoneal dialysis (CAPD) and 10 control subjects. Live vaccines were injected into 6 of the 10 children on CAPD (4 had a combined measles-mumps-rubella vaccine and the other 2 mumps vaccine). Serum antibody titres to these viruses were measured before and after vaccination. The serum IgG level was statistically lower in the CAPD group than in the control group (P<0.01), but there was no difference in the percentage of HLA-DR+CD3-cells and in the ratio of CD4 to CD8 between the two groups. There were no differences in the other parameters between the two groups. All of the 6 vaccinated children seroconverted, and serious side effects were not noted. Our results suggest that children on CAPD have no significant immune impairment.
Similar content being viewed by others
References
Kurz P, Köhler H, Meuer S, Hütteroth T, Meyer zum Buschenfelde K-H (1986) Impaired cellular immune responses in chronic renal failure: evidence for a T cell defect. Kidney Int 29:1209–1214
Weissgarten J, Modai D, Cohen N, Averbukh Z, Shaked V, Tieder M, Peller S, Kaufman S (1986) Induction of suppressor cells in normal lymphocytes by uremic serum. Int Arch Allergy Appl Immunol 81:180–183
Köhler H, Arnold W, Renschin G, Dormeyer H-H, Meyer Zum Buschenfelde K-H (1984) Active hepatitis B vaccination of dialysis patients and medical staff. Kidney Int 25:125–128
Stevens CE, Alter HJ, Taylor PE, Zang EA, Harley EJ, Szmuness W and The Dialysis Vaccine Trial Study Group (1985) Hepatitis B vaccine in patients receiving hemodialysis—immunogenicity and effeicacy. N Engl J Med 311:496–501
Drachman R, Schlesinger M, Shapira H, Drukker A (1989) The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy. Pediatr Nephrol 3:305–308
Callis LM, Clanxet J, Fortuny G, Caballeria J, Carrasco JL, Lardionois R (1985) Hepatitis B virus infection and vaccination in children undergoing hemodialysis. Acta Paediatr Scand 74:213–218
Moxey-Mims MM, Preston K, Fivush B, McCurdy F (Chesapeake Pediatric Nephrology Study Group), (1990) Hepavax-B in pediatric dialysis patients: effect of systemic lupus erythematosus. Pediatr Nephrol 4:171–173
Hara T, Hisano S, Mizuno Y, Hatae K, Kurokawa M, Ueda K, Sakaguchi T, Umene M, Mizukoshi M (1989) Systemic lupus erythematosus of childhood onset: correlation between T cells expressing early and late activation antigens and disease activity. Eur J Pediatr 148:626–629
Kikuchi M, Takeshita M, Tashiro K, Mitsui T, Eimoto T, Okamura S (1986) Immunohistological study of histiocytic necrotizing lymphadenitis. Virchows Arch [A] 409:299–311
Itoh Y, Fukumachi I, Nakajima K, Kawai T, Nakano K (1983) A new method for the evaluation of lymphocyte activation by ethidium bromide fluorescence assay. Igaku no Ayumi 126:21–22 (in Japanese)
Fivush BA, Case B, May MW, Lederman HM (1989) Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis. Pediatr Nephrol 3:186–188
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hisano, S., Miyazaki, C., Hatae, K. et al. Immune status of children on continuous ambulatory peritoneal dialysis. Pediatr Nephrol 6, 179–181 (1992). https://doi.org/10.1007/BF00866308
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00866308