Abstract
A 7-year-old boy who had been followed for asymptomatic haematuria and elevated serum IgA levels developed Henoch-Schönlein purpura (HSP) after a streptococcal infection of the tonsils. Findings on renal biopsy were compatible with mild IgA nephropathy (IgAN); tonsillectomy was also performed as he had chronic tonsillitis. This case suggests that there is a common pathogenesis for IgAN and HSP, at least in some patients.
References
Cagnoli L, Beltrandi E, Pasquali S, Biagi R, Casadei-Maldini M, Rossi L, Zuccheli P (1985) B and T cell abnormalities in patients with primary IgA nephropathy. Kidney Int 28: 646–651
Kuno-Sakai H, Sakai H, Nomoto Y, Takamura I, Kimura M (1979) Increase of IgA bearing peripheral blood lymphocytes in children with HSP. Pediatrics 64: 918–922
Davin JC, Vandenbroeck MC, Foidart JB, Mahieu PR (1985) Sequential measurements of the reticulo-endothelial system function in Henoch-Schonlein disease of childhood. Acta Paediatr Scand 74: 201–206
Meadow SR, Scott DG (1985) Berger disease: Henoch-Schonlein syndrome without the rash. J Pediatr 106: 27–32
Jennette JC, Wieslander J, Tuttle R, Falk RJ, The Glomerular Disease Collaborative Network (1991) Serum IgA-fibronectin aggregates in patients with IgA nephropathy and Henoch-Schonlein purpura: diagnostic value and pathogenic implications. Am J Kidney Dis 18: 466–471
Jones CL, Powell HR, Kincaid-Smith P, Robertson DM (1990) Polymeric IgA and immune complex concentration in IgA-related renal disease. Kidney Int 38: 323–331
Weiss JH, Bhathena DB, Curtis JJ, Lucas BA, Luke RG (1978) A possible relationship between Henoch-Schonlein syndrome and IgA nephropathy (Berger's disease). Nephron 22: 582–591
Hughes FJ, Wolfish NM, McLaine PN (1988) Henoch-Schonlein syndrome and IgA nephropathy; a case report suggesting a common pathogenesis. Pediatr Nephrol 2: 389–392
Masuda Y, Tamura S, Sugiyama N (1992) The effect of tonsillectomy and its postoperative clinical course in IgA nephropathy with chronic tonsillitis. Adv Otorhinolaryngol 47: 203–207
Waldo FB (1988) Is Henoch-Schonlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis 12: 373–377
Tomino Y, Endoh M, Nomoto Y, Sakai H (1981) Immunoglobulin A1 in IgA nephropathy. N Engl J Med 305: 1159–1160
Kusakari C, Takasaka T, Nose M, Kyogoku M (1992) IgA1 localization in tonsillar follicular dendritic cells is characteristic of IgA nephropathy. Adv Otorhinolaryngol 47: 222–226
Nagy J, brandtzaeg P, (1988) Tonsillar distribution of IgA, IgG immunocytes and IgA subclasses in IgA nephropathy. Contrib Nephrol 67: 107–110
Hene RJ, Schuurman H-J, Kater L (1988) Immunoglobulin A subclass-containing plasma cells in the jejunum in primary IgA nephropathy and in Henoch-Schonlein purpura. Nephron 48: 4–7
Williams DG (1993) Pathogenesis of idiopathic IgA nephropathy. Pediatr Nephrol 7: 303–311
Farley TA, Gillespie S, Rasoulpour M, Tolentino N, Hadler JL, Hurwitz E (1989) Epidemiology of a cluster of Henoch-Schonlein purpura. Am J Dis Child 143: 798–803
Gairdner D (1948) The Henoch-Schonlein syndrome (anaphylactoid purpura). Q J Med 17: 95–122
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Kaneko, K., Suzuki, Y., Kiya, K. et al. A case report suggesting a common pathogenesis for IgA nephropathy and Henoch-Schönlein purpura. Pediatr Nephrol 8, 750–751 (1994). https://doi.org/10.1007/BF00869110
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DOI: https://doi.org/10.1007/BF00869110